Research Topic · Peer-Reviewed

Acute Leukemia

Acute leukemia is a group of aggressive malignancies of the blood-forming tissues characterised by the clonal proliferation of immature haematopoietic precursor cells, called blasts, within the bone marrow and frequently the peripheral blood. The accumulation of these poorly differentiated cells suppresses normal ha…

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 29× across the literature 🔖 ISSN 2640-690X

Overview

Acute leukemia is a group of aggressive malignancies of the blood-forming tissues characterised by the clonal proliferation of immature haematopoietic precursor cells, called blasts, within the bone marrow and frequently the peripheral blood. The accumulation of these poorly differentiated cells suppresses normal haematopoiesis, producing anaemia, neutropenia with susceptibility to infection, and thrombocytopenia with bleeding, and may infiltrate other organs. The disease is broadly divided into acute lymphoblastic leukemia, arising from lymphoid precursors and especially common in children, and acute myeloid leukemia, arising from myeloid precursors. Pathogenesis involves acquired genetic and cytogenetic abnormalities, including chromosomal translocations and other structural rearrangements that disrupt the control of cell proliferation, differentiation, and survival; their identification underpins diagnosis, classification, and risk stratification. Diagnosis relies on morphological examination of blood and marrow together with immunophenotyping and molecular cytogenetic investigation. Acute leukemia is also associated with complications such as hypercoagulability and, in the immunocompromised neutropenic patient, opportunistic infection. Management combines cytoreductive and consolidation chemotherapy with supportive care and, in selected cases, haematopoietic stem-cell transplantation, while research continues to refine targeted and risk-adapted strategies. As a haematological emergency that may first present in primary care, acute leukemia requires prompt recognition and referral for specialist diagnosis and treatment.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

2019

Genes in Tumor Formation

Isolde RiedeCorresponding author
Exact topic Journal of Hematology and Oncology Research Cited by 2 doi:10.14302/issn.2372-6601.jhor-19-2986
2015

Epigenetics and Nutrition

Kenneth LundstromCorresponding author
International Journal of Nutrition Cited by 2 doi:10.14302/issn.2379-7835.ijn-14-603

How this research is being cited

The 12 articles above have been cited 29 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Nov 2026.

A sample of recent works citing this journal's research on Acute Leukemia, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Journal of Family Medicine (ISSN 2640-690X).

Journal editorial board
Dr. Angela Pia Cazzolla · Italy Dr. Ian James Martins · Australia Dr. Anthony Achizie Iwuafor · Nigeria

This page summarises published research for orientation; it is not medical or professional advice.