Name: Silvia Lemma

Country: Italy

Affiliation:

Department of Biomedical and Neuromotor Sciences, 
University of Bologna, 
Via Ugo Foscolo, 
7-40123 Bologna, 
Italy; 

Email: Send an Email


Address:

Orthopedic Institute Rizzoli, 
Via di Barbiano 1/10, 
40136 Bologna; 
Department of Biomedical and Neuromotor Sciences, 
University of Bologna, 
Via Ugo Foscolo, 
7- 40123 Bologna, 
‚ÄčItaly.

Research Interests:

  • Basal metabolism of the cells of the bone microenvironment: osteoclast, osteoblast, osteocyte, and mesenchymal stem cell. 
  • Adaptation of bone metabolism in pathological conditions, such as ketoacidosis.
  • Ketone bodies metabolism in osteolysis.
  • Metabolism of osteolytic bone metastasis, and strategies to prevent osteolytic lesion formation. 
  • Metabolism of benign bone tumors, including giant cell tumor of bone. 
  • Microenvironment of osteolytic diseases. 
  • The acidic microenvvironment in tumor formation and progression. 
  • Tumour microenvironment and metabolism as a target for novel therapies for patients with bone tumors. 
  • Housekeeping gene validation in cancer stem cells and microenvironment adaptations. 
  • Tumour microenvironment and metabolism as a target for novel therapies for patients with bone tumors.
  • Mechanism of drug resistance of aggressive tumors. 
  • Cancer-induced bone pain. 
  • Housekeeping gene validation in cancer stem cells and microenvironment adaptations. 
  • Chromatin compaction and post-translation modifications of histones in tumorigenesis. 
  • Mechanism underling the metastatic process in aggressive tumors.

Biography:

Scientific Peer-Reviewed Publications: 

  1. Prominent role of RAB39A-RXRB axis in cancer development and stemness. Chano T, Kita H, Avnet S, Lemma S, Baldini N. Oncotarget, in press. 
  2. MDA-MB-231 breast cancer cells fuel osteoclast metabolism and activity: a new rationale for the pathogenesis of osteolytic bone metastases. Lemma S, Di Pompo G, Porporato PE, Sboarina M, Russell S, Gillies RJ, Baldini N, Sonveaux P, Avnet S. Biochim Biophys Acta. 2017 Sep 1;1863(12):3254-3264. 
  3. Intratumoral acidosis fosters cancer-induced bone pain through the activation of the mesenchymal tumor-associated stroma in bone metastasis from breast carcinoma. Di Pompo G, Lemma S, Canti L, Rucci N, Ponzetti M, Errani C, Donati DM, Russell S, Gillies R, Chano T, Baldini N, Avnet S. Oncotarget. 2017 Apr 13;8(33):54478-54496. 
  4. Energy metabolism in osteoclast formation and activity. Lemma S, Sboarina M, Porporato PE, Zini N, Sonveaux P, Di Pompo G, Baldini N, Avnet S. Int J Biochem Cell Biol. 2016 Oct;79:168-180. 
  5. Altered pH gradient at the plasma membrane of osteosarcoma cells is a key mechanism of drug resistance. Avnet S, Lemma S, Cortini M, Pellegrini P, Perut F, Zini N, Kusuzaki K, Chano T, Grisendi G, Dominici M, De Milito A, Baldini N. Oncotarget. 2016 Sep 27;7(39):63408-63423. 
  6. Identification and Validation of Housekeeping Genes for Gene Expression Analysis of Cancer Stem Cells. Lemma S, Avnet S, Salerno M, Chano T, Baldini N. PLoS One. 2016 Feb 19;11(2):e0149481. 
  7. Modulation of TGFbeta 2 levels by lamin A in U2-OS osteoblast-like cells: understanding the osteolytic process triggered by altered lamins. Evangelisti C, Bernasconi P, Cavalcante P, Cappelletti C, D'Apice MR, Sbraccia P, Novelli G, Prencipe S, Lemma S, Baldini N, Avnet S, Squarzoni S, Martelli AM, Lattanzi G. Oncotarget. 2015 Apr 10;6(10):7424-37. 
  8. V-ATPase is a candidate therapeutic target for Ewing sarcoma. Avnet S, Di Pompo G, Lemma S, Salerno M, Perut F, Bonuccelli G, Granchi D, Zini N, Baldini N. Biochim Biophys Acta. 2013 Aug;1832(8):1105-16. 
  9. Continuous enzyme-coupled assay of phosphate- or pyrophosphate-releasing enzymes. Suárez AS, Stefan A, Lemma S, Conte E, Hochkoeppler A. Biotechniques. 2012 Aug;53(2):99-103.