Name: Laura Zaccaro

Country: Italy

Affiliation:

CNR. Istituto di Biostrutture e Bioimmagini.

Email: Send an Email


Address:

CNR. Istituto di Biostrutture e Bioimmagini,

Italy.

Research Interests:

Dr. Laura Zaccaro has gained expertise in :
• Design of peptides and peptidomimetics
• Synthesis of peptides, peptidomimetics and glycopeptides
• Structural and  physicochemical analysis of molecules by mass spectrometry and spectroscopic methods 
• Structure-activity relationship studies

Biography:

Dr. Laura Zaccaro is Researcher at Institute of Biostructures and Bioimaging of CNR in Naples- Italy
Her scientific interests concern 1) the development of new peptidic molecules able to specifically interact with molecular targets for diagnostic and therapeutic applications; 2)  structure-activity relationship studies of bioactive systems to understand the molecular features governing the biological activity. 
Over the  last years she is mainly focused on:
• design, synthesis, structural and biological characterization of peptides/peptidomimetics selective for different members of integrin receptor family and on the functionalized nanostructures for integrin selective targeting to employ in the visualization and treatment of angiogenic vessels and cancer cells in tumor diseases. 
• Structure-activity relationship studies of zinc finger proteins from prokaryotes and eukaryotes
• Synthesis and structural characterization of peptoids and glycopeptides as antimicrobials.
She is co-author of 50 peer-reviewed publications, as well as numerous proceedings, 2 patents, different lectures and invited key-notes.

Publications:

  1. Bolzati C, Salvarese N, Carpanese D, Seraglia R, Meléndez-Alafort L, Rosato A, Capasso D, Saviano M, Del Gatto A, Comegna D, Zaccaro L. “[99mTc][Tc(N)PNP43]-labeled RGD peptides as new probes for a selective detection of αvβ3 Integrin: synthesis, structure-activity and pharmacokinetic studies”. J Med Chem. 2018, 61, 9596-9610.
  2. Di Gaetano S, Del Gatto A, Pirone L, Comegna D, Zaccaro L, Saviano M, Arcà B, Capasso D, Pedone E (in stampa). “A selective avb5 integrin antagonist hidden into the anophelin family protein CE5 form the malaria vector Anopheles gambiae”. Peptide Science, Special Issue: Emerging peptide Science in Italy, 2018, e24065, doi.org/10.1002/pep2.24054
  3. L. Russo, B. Farina, A. Del Gatto,  D. Comegna,  S. Di Gaetano, D. Capasso, A. Liguoro, G. Malgieri,  M. Saviano, R. Fattorusso, L. Zaccaro. “Deciphering RGDechi peptide-a5b1 integrin interaction mode in isolated cell membranes” Peptide Science, Special Issue: Emerging peptide Science in Italy , 2018, e24065, doi.org/10.1002/pep2.24065
  4. Comegna D, Zannetti A, Del Gatto A, de Paola I, Russo L, Di Gaetano S, Liguoro A, Capasso D, Saviano M, Zaccaro L. “Chemical modification for proteolytic stabilization of the selective αvβ3 integrin RGDechi peptide: in vitro and in vivo activities on malignant melanoma cells”. J Med Chem. 2017, 60. 9874-9884. 
  5. Depalo N, Corricelli M, de Paola I, Valente G, Iacobazzi RM, Altamura E, Debellis D, Comegna D, Fanizza E, Denora N, Laquintana V, Mavelli F, Striccoli M, Saviano M, Agostiano A, Del Gatto A, Zaccaro L, Curri ML. “NIR emitting nanoprobes based on cyclic RGD motif conjugated PbS quantum dots for integrin-targeted optical bioimaging”. ACS Appl Mater Interfaces. 2017, 9, 43113-43126, doi: 10.1021/acsami.7b14155.
  6. Rosa Gaglione,  Luciano Pirone , Biancamaria Farina, Salvatore Fusco, Giovanni Smaldone, Martina Aulitto, Eliana Dell'Olmo, Emanuela Roscetto, Annarita Del Gatto, Roberto Fattorusso, Eugenio Notomista, Laura Zaccaro, Angela Arciello , Emilia Pedone, Patrizia Contursi “Insights into the anticancer properties of the first antimicrobial peptide from Archaea”, BBA-general subject 1861, 9, 2017, 2155–2164
  7. A. Bosso, L. Pirone, R. Gaglione, K. Pane, A. Del Gatto, L. Zaccaro, S. Di Gaetano, D. Diana, R. Fattorusso, E. Pedone, V. Cafaro, H.P. Haagsman, A. van Dijk, M.R. Scheenstra, A. Zanfardino, O. Crescenzi, A. Arciello, M. Varcamonti, E.J.A. Veldhuizen, A. Di Donato, E. Notomista, E. Pizzo “A new cryptic host defense peptide identified in human 11-hydroxysteroid dehydrogenase-1 β-like: from in silico identification to experimental evidence , BBA –general Subjects , 2017, 1861, 2342-2353.
  8. Persico M, Fattorusso R, Taglialatela-Scafati O, Chianese G, de Paola I, Zaccaro L Rondinelli F, Lombardo M, Quintavalla A, Trombini C, Fattorusso E, Fattorusso C, Farina B. “The interaction of heme with plakortin and a synthetic endoperoxide analogue: new insights into the heme-activated antimalarial mechanism” Sci Rep. 2017, 7:45485. doi: 10.1038/srep45485.
  9. P. Di Pietro, L. Zaccaro, D. Comegna, A. Del Gatto, M. Saviano, R. Snyders, D. Cossement, C.Satriano and Enrico Rizzarelli "Silver nanoparticles functionalized with a fluorescent cyclic RGD peptide: a versatile integrin targeting platform for cells and bacteria, RSC Advanced 2016, 6, 112381-112392; doi: 10.1039/c6ra21568h
  10. D'Abrosca G, Russo L, Palmieri M, Baglivo I, Netti F, de Paola I, Zaccaro L, Farina B, Iacovino R, Pedone PV, Isernia C, Fattorusso R, Malgieri G. The (unusual) aspartic acid in the metal coordination sphere of the prokaryotic zinc finger domain. J Inorg Biochem, 2016, Aug;161:91-8. doi: 10.1016/j.jinorgbio.2016.05.006. 
  11. Valente G,. Depalo N., de Paola I., Iacobazzi R. M., Denora N., Laquintana V., Comparelli R., Altamura E., Latronico T., Altomare .M, Fanizza E., Striccoli M., Agostiano A., Saviano M., Del Gatto A., Zaccaro L*. and Curri M. L*. Integrin targeting with peptide bioconjugated to semiconductor-magnetic nanocrystalline heterostructures, Nanoresearch, 2016, 644-662. 
  12. *Co-corresponding
  13. Farina B, de Paola I, Russo L, Capasso D, Liguoro A, Del Gatto A, Saviano M, Pedone PV, Di Gaetano S, Malgieri G, Zaccaro L*, Fattorusso R*. A Combined NMR and Computational Approach to Determine the RGDechi-hCit-αv β3 Integrin Recognition Mode in Isolated Cell Membranes. Chemistry. 2016,  22, 681-93 doi: 10.1002/chem.201503126. 
  14.  *Co-corresponding
  15. de Paola I, Pirone L, Palmieri M, Balasco N, Esposito L, Russo L, Mazzà D, Di Marcotullio L, Di Gaetano S, Malgieri G, Vitagliano L, Pedone E, Zaccaro L. Cullin3 - BTB Interface: A Novel Target for Stapled Peptides. PLoS One. 2015,;10, e0121149. doi: 10.1371/journal.pone.0121149. 
  16. Comegna D, de Paola I, Saviano M, Del Gatto A, Zaccaro L. Straightforward entry to s-glycosylated fmoc-amino acids and their application to solid phase synthesis of glycopeptides and glycopeptidomimetics. Org Lett. 2015, 6; 640-3