Name: Hem D Shukla

Country: United States

Affiliation:

Faculty Department of Biology,
University System of Maryland.

Email: Send an Email


Address:

Baltimore, MD 21201,
United States.

Research Interests:

  • Biomarker Discovery (physical principles of the architecture of biological macromolecules, proteins, nucleic acids and their complexes, namely the ene.
  • Proteomic analysis of oxidative stress response in BxPC-3 pancreatic cell lines Identification of biomarkers for pancreatic cancer 
  • Nrf2 mediated antioxidant defense against oxidative stress in pancreatic cancer cell lines

Biography:

  • Hem D. Shukla is Research Scientist in Department of Pharmaceutical Sciences at University of Maryland and adjunct Professor of Genomics in Notredame of Maryland University. 
  • He has also worked as Research Faculty in Department of Biology at Johns Hopkins University. 
  • Dr. Shukla has worked on proteomic analysis of oxidative stress response in BxPC-3 pancreatic cell lines and identification of biomarkers for pancreatic cancer. 
  • He has worked on “The Nrf2 mediated antioxidant defense against oxidative stress in pancreatic cancer cell lines and targets for therapeutic intervention”. 
  • He has shown elevated level of Nrf2 transcriptional factor in pancreatic cancer cell lines under oxidative stress which is phosphorylated by protein kinase C and affects phosphatidylinositol 3-kinase and MAP kinase pathways. 
  • After phosphorylation, Nrf2 translocates to the nucleus, binds AREs and transactivates detoxifying enzymes and antioxidant enzymes, such as glutathione S-transferase, and superoxide dismutase. 
  • The IPA analysis has suggested a potential role of Nrf2 under oxidative stress conditions.
  • Currently, working as professor in Department of Biology at University of Maryland.
  • Previously, I have worked as Staff Scientist and Director of Proteomic Core in National Institute on Aging, NIH.
  • My expertize is on Pancreatic Cancer Biomarker Discovery.

Publications:

http://www.ncbi.nlm.nih.gov/pubmed/?term=shukla+hd
http://www.omicsonline.org/2155-9929/2155-9929-S1.017-007.pdf