Baltimore, MD 21201,
- Biomarker Discovery (physical principles of the architecture of biological macromolecules, proteins, nucleic acids and their complexes, namely the ene.
- Proteomic analysis of oxidative stress response in BxPC-3 pancreatic cell lines Identification of biomarkers for pancreatic cancer
- Nrf2 mediated antioxidant defense against oxidative stress in pancreatic cancer cell lines
- Hem D. Shukla is Research Scientist in Department of Pharmaceutical Sciences at University of Maryland and adjunct Professor of Genomics in Notredame of Maryland University.
- He has also worked as Research Faculty in Department of Biology at Johns Hopkins University.
- Dr. Shukla has worked on proteomic analysis of oxidative stress response in BxPC-3 pancreatic cell lines and identification of biomarkers for pancreatic cancer.
- He has worked on “The Nrf2 mediated antioxidant defense against oxidative stress in pancreatic cancer cell lines and targets for therapeutic intervention”.
- He has shown elevated level of Nrf2 transcriptional factor in pancreatic cancer cell lines under oxidative stress which is phosphorylated by protein kinase C and affects phosphatidylinositol 3-kinase and MAP kinase pathways.
- After phosphorylation, Nrf2 translocates to the nucleus, binds AREs and transactivates detoxifying enzymes and antioxidant enzymes, such as glutathione S-transferase, and superoxide dismutase.
- The IPA analysis has suggested a potential role of Nrf2 under oxidative stress conditions.
- Currently, working as professor in Department of Biology at University of Maryland.
- Previously, I have worked as Staff Scientist and Director of Proteomic Core in National Institute on Aging, NIH.
- My expertize is on Pancreatic Cancer Biomarker Discovery.