Name: Hehuang Xie

Country: United States


Virginia Bioinformatics Institute

Email: Send an Email


1015 Life Science Circle
Blacksburg, VA 24061-0477
United States

Research Interests:

  • The primary research interest of Xie's group is to understand the molecular mechanisms underlying epigenetic transitions during important biological processes associated with human complex diseases. 
  • Toward this goal, my group emphasizes the development of high-throughput sequencing approaches for data generation and the implementation of computational tools for -omics data analysis. 
  • In particular, the group is interested in strategies to monitor the fidelity of DNA methylation inheritance, assess methylation variation within and between cell populations, identify true epimutations, and, eventually, discover novel therapies. 
  • Our previous studies include bio-technique development to facilitate targeted epigenome sequencing, CpG islands and Alu repeats in particular ; and model establishment to assess DNA methylation variations and simulate epigenetic state transitions during stem cell differentiation, reprogramming and disease genesis. 
  • We have successfully applied techniques and bioinformatics tools to identify diagnosis markers for diseases.


  • Dr. Hehuang Xie graduated from the University of Iowa with Ph.D. in genetics and a master degree in computer science in 2003. 
  • After his graduate studies, Dr. Xie received his postdoctoral training in the field of bioinformatics at The University of Iowa and The University of Minnesota. 
  • In 2005, Dr. Xie joined the Cancer Biology and Epigenomics Program, Children Memorial Research Center; 
  • Department of Pediatrics, Northwestern University as a research faculty. 
  • Currently, Dr. Xie is an associate professor at the Virginia Bioinformatics Institute.