280, Chong-Qing South Road
Leukemia, hepatocellular carcinoma, chemical biology, signaling pathway, cell differentiation and death
- Professor Guoqiang CHEN, president of Shanghai Jiao Tong University School of Medicine, the Vice President of Shanghai Jiao Tong University, Director of Key Laboratory of Cell Differentiation and Apoptosis of Ministry of Education, got his PhD in Hematology from Shanghai Second Medical University in 1996.
- He has been devoting his efforts to investigate oncogenesis, leukemic cell differentiation and apoptosis and target therapy.
- For instances, he made important contribution to put arsenic trioxide into worldwide-used effective drug for the treatment of acute promyelocytic leukemia (APL), a unique subtype of acute myeloid leukemia.
- He also found the role of hypoxia/hypoxia-inducible factor-1alpha (HIF-1a)/C/EBPa and Runx1 signaling axis as well as phospholipid scramblase 1 in leukemic cell differentiation, and reported that Cbx4 governs HIF-1ÃŽÂ± to potentiate angiogenesis of hepatocellular carcinoma by its SUMO E3 ligase activity.
- He also identifies some natural anti-tumor/leukemia compounds such as adenanthin and their targets. With these discoveries,
- Dr. Chen has published over 130 peer-reviewing articles on the international journals such as Cancer Cell, Blood, Leukemia, Nature Chemical Biol, J Natl Cancer Inst, Nature Cell Biol, Nature Communication.
- Due to his great academic contributions, Professor Chen was awarded National Nature Science Reward, National Medicine and Technology Reward, Shanghai Nature Sci Award, Shanghai Science and Technology Progress Awards and others.
- Fan X, Shi P, Dai J, Lu Y, Chen X, Liu X, Zhang K, Wu X, Sun Y, Wang K, Zhu L, Zhang CC, Zhang J, Chen GQ, Zheng J, Liu J. Paired immunoglobin-like receptor B regulates platelet activation. Blood. 2014 Jul 29. pii: blood-2014-03-557645. [Epub ahead of print]
- Wen D, Xu Z, Xia L, Liu X, Tu Y, Lei H, Wang W, Wang T, Song L, Ma C, Xu H, Zhu W, Chen GQ, Wu Y. Important Role of SUMOylation of Spliceosome Factors in Prostate Cancer Cells. J Proteome Res. 2014 Aug 1;13(8):3571-82
- Li J, Xu Y, Jiao H, Wang W, Mei Z, Chen GQ. Sumoylation of hypoxia inducible factor-1ÃŽÂ± and its significance in cancer. Sci China Life Sci. 2014 Jul;57(7):657-64. doi: 10.1007/s11427-014-4685-3. Epub 2014 Jun 11.
- Mei Z, Jiao H, Wang W, Li J, Chen GQ, Xu Y. Polycomb chromobox 4 enhances migration and pulmonary metastasis of hepatocellular carcinoma cell line MHCC97L.Sci China Life Sci. 2014 Jun;57(6):610-7.
- Duan CW, Shi J, Chen Ji, Wang B, Yu YH, Qin X, Zhou XC, Cai YJ, Li ZQ, Zhang F, Yin M, Tao Y, Mi JQ, Li LH, Enver T, Chen GQ, Hong DL. Leukemia Propagating Cells Rebuild an Evolving Niche in Response to Therapy. Cancer Cell, 2014 Jun 16;25(6):778-9.
- Li J, Xu Y, Long XD, Wang W, Jiao HK, Mei Z, Yin QQ, Ma LN, Zhou AW, Wang LS, Yao M, Xia Q, Chen GQ. Cbx4 Governs HIF-1ÃŽÂ± to Potentiate Angiogenesis of Hepatocellular Carcinoma by Its SUMO E3 Ligase Activity. Cancer Cell. 2014 Jan 13;25(1):118-31.
- Zheng J, Lu Z, Kocabas F, BÃƒÂ¶ttcher RT, Costell M, Kang X, Liu X, Deberardinis RJ, Wang Q, Chen GQ, Sadek H, Zhang CC. Profilin 1 is essential for retention and metabolism of mouse hematopoietic stem cells in bone marrow. Blood. 2014Ã¯Â¼â€º123(7):992-1001
- Yin QQ, Liu CX, Wu YL, Wu SF, Wang Y, Zhang X, Hu XJ, Pu JX, Lu Y, Zhou HC, Wang HL, Nie H, Sun HD, Chen GQ. Preventive and Therapeutic Effects of Adenanthin on Experimental Autoimmune Encephalomyelitis by Inhibiting NF-ÃŽÂºB Signaling. J Immunol. 2013 Sep 1;191(5):2115-25.
- Xia L, Wang TD, Shen SM, Zhao M, Sun H, He Y, Xie L, Wu ZX, Han SF, Wang LS, Chen GQ. Phosphoproteomics Study on the Activated PKCÃŽÂ´-Induced Cell Death. J Proteome Res. 2013 Oct 4;12(10):4280-301
- Wang L, Liu T, Xu L, Gao Y, Wei Y, Duan C, Chen GQ, Lin S, Patient R, Zhang B, Hong D, Liu F. Fev regulates hematopoietic stem cell development via ERK signaling. Blood. 2013 Jul 18;122(3):367-75.