Emilia Pedone

Address:

Italian National Research Council, 
CNR · Institute of Biostructure and Bioimaging IBB, 
Italy.

Research Interests:

• Molecular Biology 
• Proteins 
• ELISA 
• Structural Biology 
• Protein Stability 
• Protein Conformation.

Biography:

• Emilia Pedone is Researcher at Institute of Biostructures and Bioimaging of C.N.R in Naples, Italy. 
• Her prevailing interest is the study of the structure-function relationship regarding different protein targets and protein-protein interactions involved in the insurgence of several pathologies. 
• She has gained expertise in the main techniques of microbiology, biochemistry and molecular biology. In addition she has acquired technical skills for the expression of heterologous proteins in organisms such as Escherichia coli or insect cells or labeled proteins for the resolution of the structure by NMR or X-ray crystallography. 
• Moreover she gained the know-how of biophysical methodologies such as CD, light scattering, SPR, ITC, spectrofluorimetry and thermophoresis for the study of protein-protein, protein-peptide, protein-DNA interactions.

Publications:

1: Malgieri G, D'Abrosca G, Pirone L, Toto A, Palmieri M, Russo L, Sciacca MFM, Tatè R, Sivo V, Baglivo I, Majewska R, Coletta M, Pedone PV, Isernia C, De Stefano M, Gianni S, Pedone EM, Milardi D, Fattorusso R. Folding mechanisms steer the amyloid fibril formation propensity of highly homologous proteins. Chem Sci. 2018 Mar 1;9(13):3290-3298. doi: 10.1039/c8sc00166a. eCollection 2018 Apr 7.
2: Smaldone G, Pirone L, Capolupo A, Vitagliano L, Monti MC, Di Gaetano S, Pedone E. The essential player in adipogenesis GRP78 is a novel KCTD15 interactor. Int J Biol Macromol. 2018 Apr 14;115:469-475. doi: 10.1016/j.ijbiomac.2018.04.078.
3: Baglivo I, Pirone L, Malgieri G, Fattorusso R, Roop Ii RM, Pedone EM, Pedone PV. MucR binds multiple target sites in the promoter of its own gene and is a heat-stable protein: Is MucR a H-NS-like protein? FEBS Open Bio. 2018 Mar 31;8(4):711-718. doi: 10.1002/2211-5463.12411. eCollection 2018 
4: Fusco FA, Fiorentino G, Pedone E, Contursi P, Bartolucci S, Limauro D. Biochemical characterization of a novel thermostable β-glucosidase from Dictyoglomus turgidum. Int J Biol Macromol. 2018 Jul 1;113:783-791. doi: 10.1016/j.ijbiomac.2018.03.018. 
5: Ferrucci V, de Antonellis P, Pennino FP, Asadzadeh F, Virgilio A, Montanaro D, Galeone A, Boffa I, Pisano I, Scognamiglio I, Navas L, Diana D, Pedone E, Gargiulo S, Gramanzini M, Brunetti A, Danielson L, Carotenuto M, Liguori L, Verrico A, Quaglietta L, Errico ME, Del Monaco V, D'Argenio V, Tirone F, Mastronuzzi A, Donofrio V, Giangaspero F, Picard D, Remke M, Garzia L, Daniels C, Delattre O, Swartling FJ, Weiss WA, Salvatore F, Fattorusso R, Chesler L, Taylor  MD, Cinalli G, Zollo M. Metastatic group 3 medulloblastoma is driven by PRUNE1 targeting NME1-TGF-β-OTX2-SNAIL via PTEN inhibition. Brain. 2018 May 1;141(5):1300-1319. doi: 10.1093/brain/awy039. 
6: Mercurio FA, Di Natale C, Pirone L, Iannitti R, Marasco D, Pedone EM, Palumbo  R, Leone M. The Sam-Sam interaction between Ship2 and the EphA2 receptor: design  and analysis of peptide inhibitors. Sci Rep. 2017 Dec 12;7(1):17474. doi: 10.1038/s41598-017-17684-5. 
7: Fusco FA, Ronca R, Fiorentino G, Pedone E, Contursi P, Bartolucci S, Limauro D. Biochemical characterization of a thermostable endomannanase/endoglucanase from Dictyoglomus turgidum. Extremophiles. 2018 Jan;22(1):131-140. doi: 10.1007/s00792-017-0983-6. 
8: Gaglione R, Smaldone G, Di Girolamo R, Piccoli R, Pedone E, Arciello A. Cell milieu significantly affects the fate of AApoAI amyloidogenic variants: predestination or serendipity? Biochim Biophys Acta. 2018 Mar;1862(3):377-384. doi: 10.1016/j.bbagen.2017.11.018
9: Baglivo I, Pirone L, Pedone EM, Pitzer JE, Muscariello L, Marino MM, Malgieri  G, Freschi A, Chambery A, Roop Ii RM, Pedone PV. Ml proteins from Mesorhizobium loti and MucR from Brucella abortus: an AT-rich core DNA-target site and oligomerization ability. Sci Rep. 2017 Nov 17;7(1):15805. doi: 10.1038/s41598-017-16127-5. 
10: Gaglione R, Pirone L, Farina B, Fusco S, Smaldone G, Aulitto M, Dell'Olmo E,  Roscetto E, Del Gatto A, Fattorusso R, Notomista E, Zaccaro L, Arciello A, Pedone E, Contursi P. Insights into the anticancer properties of the first antimicrobial peptide from Archaea. Biochim Biophys Acta. 2017 Sep;1861(9):2155-2164. doi: 10.1016/j.bbagen.2017.06.009.