Name: Elena Orlova

Country: United Kingdom

Affiliation:

Institute for Structural and Molecular Biology,
Department of Biological Sciences,
Birkbeck College

Phone no: 020 7631 6845

Email: Send an Email


Address:

Malet St,
London WC1E 7HX, UK

Research Interests:

Bacteriophage assembly, Structural analysis of the transcription factor p53 Electron cryo-microscopy and image processing, Human MCM10 replication factor,Electron cryo-microscopy and image processing, Development of methods for recognition and separation of heterogeneous molecular complexe

Biography:

Publications

  1. White HE, Sherman MB, Brasils S, Jacquet E, Seavers P, Tavares P, Orlova EV. (2012) Capsid structure and its Stability at the Late Stages of Bacteriophage SPP1 Assembly. J Virol. Apr 18. [Epub ahead of print]
  2. Orlova EV, (2011), Bacteriophages and their structural organisation. In Bacteriophages, (Ed. Kurtboke) InTech Open, open access publisher,3-30.
  3. Tavares P., Zinn-Justin S., and Orlova, E.V. (2011). Genome gating in tailed bacteriophage capsids. In Viral Molecular Machines (M.G. Rossmann, V.B. Rao, eds.), Springer, New York, 585-600 (1)
  4. Orlova EV, Saibil HR, (2011) Structural analysis of macromolecular assemblies by electron microscopy. Chemical Reviews, 111(12), 7710-7748 (2)

  5. R. Aramayo, M. B. Sherman, K. Brownless, A. L. Okorokov and E. V. Orlova. (2011) Quaternary structure of the specific p53-DNA complex reveals the mechanism of p53 mutant dominance. NAR, 39 (20), 8960-8971 (1).
  6. Law RHP, Lukoyanova N, Voskoboinik I, Caradoc-Davies TT, Baran K, Dunstone MA, Angelo MED, Orlova EV, Coulibaly F, Verschoor S, Browne KA, Ciccone A, Kuiper MJ, Bird FI, Trapani JA, Saibil HR, Whisstock JC. (2010) The structural basis for membrane binding and pore formation by lymphocyte perforin. Nature, 468, 447-51.(23)
  7. Orlova EV, Saibil HR.(2010) Methods for three-dimensional reconstruction of heterogeneous assemblies. Methods Enzymol.,482, 321-41, Review.(5)
  8. Clare DK, Orlova EV. (2010)4.6A Cryo-EM reconstruction of tobacco mosaic virus from images recorded at 300keV on a 4kx4k CCD camera. J Struct Biol. 171, 303-308. (7)
  9. Okorokov AL, Chaban YL, Bugreev DV, Hodgkinson J, Mazin AV, Orlova EV. Structure of the hDmc1-ssDNA filament reveals the principles of its architecture. (2010) PLoS One. 5(1):e8586 (4)
  10. Lhuillier S, Gallopin M, Gilquin B, Brasils S, Lancelot N, Letellier G, Gilles M, Dethan G, Orlova EV, Couprie J, Tavares P, Zinn-Justin S. (2009) Structure of bacteriophage SPP1 head-to-tail connection reveals mechanism for viral DNA gating. Proc Natl Acad Sci USA. 106(21), 8507-8512.
  11. Orlova EV. How viruses infect bacteria? (2009) EMBO J. 28(7), 797-798.