Name: Elaine O'Loughlin

Country: United States

Affiliation:

Associate Scientist,
PostDoc Fellow.

Email: Send an Email


Address:

Merck Research Labs ,
33 Avenue Louis Pasteur,  
BMB-8-111,  
Boston MA 02115.

Research Interests:

Epilepsy, Neurobehaviour, Glia (Microglia), Neuroinflammation, Neurodegeneration

Biography:

  • Contribution of amygdala pathology to comorbid emotional disturbances in temporal lobe epilepsy.
  • The brain parenchyma has a type I interferon response that can limit virus spread.
  • Differential contribution of microglia and monocytes in neurodegenerative diseases.
  • The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases.
  • Effect of maternal immune activation on pre- and postnatal murine brain development.
  • Interdependent and independent roles of type I interferons and IL-6 in innate immune, neuroinflammatory and sickness behaviour responses to systemic poly I:C.
  • Expression of neuropeptide Y1 receptors in the amygdala and hippocampus and anxiety-like behavior associated with Ammon's horn sclerosis following intrahippocampal kainate injection in C57BL/6J mice.
  • The role of type-interferons in poly I:C induced sickness behaviour.