Golden Jubilee National Hospital,
Agamemnon st Clydebank, Glasgow,
- Tissue engineering and biomaterials and regenerative medicine
- Stem cells differentiation and cell therapy
- Clinical applied proteomic analysis
- Cardiac surgery and molecular basis of inflammation in atherosclerosis
- Immunology in cardiovascular disorders
- Dr Cristiano Spadaccio is a cardiothoracic surgeon at the Golden Jubilee National Hospital in Glasgow, UK and an Honorary Clinical Lecturer at the University of Glasgow in the College of Medicine Veterinary and Life Science affiliated to the Institute of Cardiovascular and Medical Sciences.
- He graduated as medical doctor at the University Campus Bio-Medico of Rome in 2006.
- He obtained and completed a postdoctoral training at the University of Pittsburgh Medical Center at the department of Cardiovascular Surgery and at the McGowan Institute for Regenerative Medicine where he was dedicated to stem cell differentiation, 3D culture using bioresorbable scaffolds and development of 3D systems for stem cells differentiation.
- He obtained his PhD degree at the University La Sapienza of Rome in 2009 working on tissue engineering of heart, vessels, bone and muscles.
- He has also been associate visiting investigator at the unit of translational medicine and research at the universitary hospital Dr Negrin, Spain where he dedicated to the in vivo application of bioresorbable scaffolds for cardiovascular translational purposes.
- He is also among the founders of a biomedical engineering company involved in regenerative medicine named Biomatica Ltd.
- From the clinical point of view Dr Spadaccio is dedicated to minimally invasive cardiac surgery for both the aortic and mitral valve and to off-pump techniques for coronary surgery.
- He is also interested in transcatheter procedures for aortic and mitral valve and in the development of medical devices and alternative access routes to cardiovascular structures, as testified by his clinical research activities.
- He is also the coordinator of several international clinical studies involving coronary and valve surgery.
- His basic science research activity is focused on several themes related to stem cells differentiation, tissue engineering and regenerative medicine with particular attention to biofunctionalization of resorbable materials for tissue regeneration and to translational aspects of tissue engineering.
- Considering his expertise in cardiovascular surgery, he developed clinically translatable small and large animal models of cardiac and vascular disease focusing on the application of biomaterials and drug delivery systems in routine clinical scenarios.
- In this context, his experimental efforts, raised from several collaborative activities with other groups, led to the production of a functionalized-heparin releasing scaffold for vascular replacement, a functionalized myocardial patch for ventricular restoration, a bioresorbable device for sternal synthesis after cardiac surgery and several tissue engineering-based approaches for diabetic wound repair.
- He is also focused on the study of the biological properties of the extracellular matrix and on the development of ECM-like biological surrogates to stimulate tissue regeneration, in particular using electrospinning techniques.
- Additionally, he dedicated to the elucidation of several biomolecular aspects of cardiovascular degenerative and inflammatory diseases and to the identification of markers of pathologies through proteomic approaches.
- He scientific and clinical activity is testified by several papers published on international peer reviewed journal and presented his results in a number of international society meetings including the American College of Cardiology, the American Association for Thoracic Surgery, The European Association for Cardiothoracic Surgery, the International Society of Minimally Invasive Cardiothoracic Surgery, the International Society of Stem Cells research, The American Society of Artificial Organs in USA, the Tissue Engineering and Regenerative Medicine Society in Europe and the International Cardiac BioAssist Association in Singapore.
- He has applied for international grants related to his work sponsored by NIH and other institutions.
- He organized cooperative consortia for research projects with many research groups.
- He is currently the lead guest editor for a supplement of the Journal Drug Target Insights focused on drug delivery devices, guest Editor for and serves as reviewer for both clinical and biomedical journals.