International Journal of Neuroimaging

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International Journal of Neuroimaging-Advanced Neuroradiology MRI Techniques-Christopher Thomas Whitlow

United States



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Christopher Thomas Whitlow


Division of Radiologic Sciences Department of Radiology Section of Neuroradiology Wake Forest School of Medicine Medical Center Boulevard Winston-Salem, 
NC 27157-1088.

Research Interests:

  • Advanced Neuroradiology MRI Techniques, 
  • Neuroradiology, 
  • Radiology.


  • I am a NIH R01-funded principal-investigator at Wake Forest School of Medicine (WFSM), where I have crossdisciplinary appointments as an Associate Professor in the Department of Radiology, Department of Biomedical Engineering, Department of Biostatistical Sciences (Division of Public Health Sciences) and Clinical Translational Sciences Institute (CTSI). In the Department of Radiology, I serve as Chief of Neuroradiology and Vice Chair of Informatics. 
  • I also serve as director of the CTSI Translational Imaging Program, managing all institutional imaging research at WFSM. 
  • In addition, I am the founder/director of the Radiology Informatics and Image Processing Laboratory (RIIPL). 
  • RIIPL focuses on high throughput “big data” processing and analysis of multimodal imaging data (e.g., magnetic resonance imaging, positron emission tomography, magnetoencephalography) across a number of species, including humans, non-human primates, swine and rodents. As a neuroimaging physicianscientist, I have specific doctoral training in neurophysiology and neuropharmacology, which has allowed me to develop new imaging protocols and techniques for novel in vivo imaging. 
  • I also have a strong informatics background and extensive training in epidemiology/public health research methodologies as a graduate of the Gillings School of Global Public Health at University of North Carolina Chapel Hill. 
  • Taken together, my training and experience has provided me with the critical skills necessary to lead large-scale translational studies of disease at the population level. 
  • In addition to my own R01 funded work, I presently direct the image processing efforts of our recently funded Cancer Center P01 (CA207206-01A1) and Alzheimer’s Disease Center (P30 AG049638), as well as several other collaborative NIH funded projects listed below. 
  • As a board-certified Diagnostic Radiologist with focused subspecialty fellowship training in neuroradiology, I have interpreted thousands of computed tomography, magnetic resonance imaging and other imaging studies to evaluate a variety of complex pathologic processes across the spectrum of disease. 
  • My clinical and research neuroimaging experience has resulted in appointments at the national level, including the Research Committees of the Christopher T. 
  • Whitlow Curriculum Vitae Page 8 American Society of Neuroradiology (ASNR), American Society of Functional Neuroradiology, and American College of Radiology (ACR) Head Injury Institute. 
  • I am also co-chair of the Traumatic Brian Injury-Reporting and Data System (TBI-RADS) Committee of the ACR Head Injury Institute that is developing national standards for brain imaging data acquisition and clinical reporting in the setting of traumatic brain injury. 
  • As co-chair of the international multidisciplinary ASNR Study Group for the Clinical Translation of Advanced Diffusion and Functional MRI, I am working to develop new neuroimaging biomarkers for a variety of diseases that affect the brain. 
  • These efforts overlap with my role as Co-Chair of the DTI Profile Committee for the RSNA Quantitative Imaging Biomarkers Alliance. 
  • Through my research, clinical practice and national/international service, I am at the cutting edge of neuroimaging translation from bench-top to clinical practice.

Honours and Awards:

  • 1994 University Book Exchange Scholarship 
  • 1997 Magna cum laude with honors in Psychology 
  • 1998 M.D./Ph.D. Academic Scholarship 
  • 1998-2004 National Institutes of Health NRSA M.D./Ph.D. Predoctoral Fellowship Grant 
  • 1999 WFU School of Medicine Medical Student Research Day Poster Award: Persistent effects of the acute administration of ∆⁹-tetrahydrocannabinol on rates of local cerebral glucose utilization in the rat.
  •  2000-2002 President, Student Interest Group in Neurology 
  • 2001 National Institute on Drug Abuse Travel Award: ICRS Annual Meeting 
  • 2003 Alpha Omega Alpha Honor Medical Society 
  • 2004 Published Art: Mantle. Oil glaze on canvas. JAMA. 
  • 2004; 2291: 1639-1640 2004 Richard L. Burt Research Achievement Award 
  • 2004 I. Meschan Radiology Merit Award 
  • 2004 Medical Student Prize for Excellence in Neurology, American Academy of Neurology 2006 Introduction to Research Program, Radiological Society of North America 
  • 2007 Presidents Circle Research & Education Foundation Research Resident Grant, Radiological Society of North America 
  • 2007 Editorial Fellowship for Trainees, Radiological Society of North America.


  1. Porrino LJ, Williams-Hemby L, Whitlow C, Bowen C, Samson HH. Metabolic mapping of the effects of oral alcohol self-administration in rats. Alcohol Clin Exp Res 1998;22:176-82. 
  2. Porrino LJ, Whitlow CT, Samson HH, Effects of the self-administration of ethanol and ethanol/sucrose on rates of local cerebral glucose utilization in rats. Brain Res 1998;791:18-26. Lyons D, Whitlow CT, Porrino LJ. Multiphasic consequences of the acute administration of ethanol on cerebral glucose metabolism in the rat. Pharmacol Biochem Behav 1998;61:201-6. 
  3. Lyons D, Whitlow CT, Smith HR, Porrino LJ. Brain imaging. Functional consequences of ethanol in the central nervous system. Recent Dev Alcohol 1998;14:253-84. **
  4. Whitlow CT, Freedland CS, Porrino LJ. Metabolic mapping of the time-dependent effects of Delta9- tetrahydrocannabinol administration in the rat. Psychopharmacology (Berl) 2002;161:129-36. 
  5. Freedland CS, Whitlow CT, Miller MD, Porrino LJ. Dose-dependent effects of Delta9- tetrahydrocannabinol on rates of local cerebral glucose utilization in rat. Synapse 2002;45:134-42. 
  6. Freedland CS, Whitlow CT, Smith HR, Porrino LJ. Functional consequences of the acute administration of the cannabinoid receptor antagonist, SR141716A, in cannabinoid-naïve and-tolerant animals: a quantitative 2-[ 14C] deoxyglucose study. Brain Res 2003;962:169-79. **
  7. Whitlow CT, Freedland CS, Porrino LJ, Functional consequences of the repeated administration of Delta9-tetrahydrocannabinol in the rat. Drug Alcohol Depend 2003;71:169-77. 
  8. Macey DJ, Rice WN, Freedland CS, Whitlow CT, Porrino LJ. Patterns of functional activity associated with cocaine self-administration in the rat change over time. Psychopharmacology (Berl) 2004;172:384-92. *Whitlow CT, Liguori A, Livengood LB, Hart SL, Mussat-Whitlow BJ, Lamborn CM, Laurienti PJ, Porrino LJ. Long-term heavy marijuana users make costly decisions on a gambling task. Drug Alcohol Depend 2004;76:107-11.