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Italy

FIRC Institute of Molecular Oncology Foundation, Milano

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Chiara Bruckmann

Address:

IFOM - The FIRC Institute of Molecular Oncology Milan, Italy.

Research Interests:

Molecular Biosciences, Chemical Biology, Molecular Biosciences, Structural Biology

Biography:

  1. A tale of TALE, PREP1, PBX1, and MEIS1: Interconnections and competition in cancer.
  2. New insights into cooperative binding of homeodomain transcription factors PREP1 and PBX1 to DNA.
  3. The flexibility of a homeodomain transcription factor heterodimer and its allosteric regulation by DNA binding.
  4. Purification and Characterization of a DNA-Binding Recombinant PREP1:PBX1 Complex.
  5. Systematic Structure-Activity Study on Potential Chaperone Lead Compounds for Acid α-Glucosidase.
  6. Oxygen activation in neuronal NO synthase: resolving the consecutive mono-oxygenation steps.
  7. Histidine 55 of tryptophan 2,3-dioxygenase is not an active site base but regulates catalysis by controlling substrate binding.
  8. Molecular insights into substrate recognition and catalysis by tryptophan 2,3-dioxygenase.
  9. Structure of a proteolytically resistant core from the severe acute respiratory syndrome coronavirus S2 fusion protein.
  10. Structural characterization of the fusion-active complex of severe acute respiratory syndrome (SARS) coronavirus.