Journal of Alcohol

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Alcohol -Ethanol-Anushree Karkhanis

United States

Assistant Professor,
Physiology & Pharmacology Instructor,
Physiology & Pharmacology Office of Women in Medicine and Science.


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Anushree Karkhanis


Assistant Professor,
Department of Physiology and Pharmacology,
Wake Forest School of Medicine,
Medical Center Blvd.,
Winston-Salem, NC 27157.

Research Interests:

Ethanol, Norepinephrine, Dopamine, Nucleus Accumbens, Social Isolation.


  1. Social isolation stress increases KAPPA opioid receptor function on dopamine terminals in the nucleus accumbens of rats [abstract]. Karkhanis AN, Leussen D, Weiner JL, Chen R, Jones SR.. Alcohol. 2017;60():215.
  2. Regulation of dopamine and dynorphin/KOR function by chronic ethanol and withdrawal in mice and monkeys [abstract]. Holleran KM, Karkhanis A, Rose JH, Siciliano CA, Grant KA, Jones SR.. Alcohol. 2017;60():220.
  3. Chronic stress and ethanol-mediated alterations in norepineprhine transmission in mesolimbic circuitry [abstract]. Karkhanis AN, Jones SR.. Alcohol Clin Exp Res. 2017;41(Suppl 1):323A.
  4. Early life stress-potentiated cocaine seeking is mediated by upregulation of kappa opioid receptor function [abstract]. Karkhanis AN, Albertson SE, Weiner JL, Jones SR.. FASEB J. 2017;31(Suppl 1):986.12.
  5. Dynorphin/kappa opioid receptor signaling in preclinical models of alcohol, drug, and food addiction. Karkhanis A, Holleran KM, Jones SR.. Int Rev Neurobiol. 2017;136():53-88.
  6. Adolescent social isolation as a model of heightened vulnerability to comorbid alcoholism and anxiety disorders. Butler TR, Karkhanis AN, Jones SR, Weiner JL.. Alcohol Clin Exp Res. 2016;40(6):1202-1214.
  7. The individual and combined effects of phenmetrazine and mgluR2/3 agonist LY379268 on the motivation to self-administer cocaine. Karkhanis AN, Beveridge TJ, Blough BE, Jones SR, Ferris MJ.. Drug Alcohol Depend. 2016;166():51-60.
  8. Switch from excitatory to inhibitory actions of ethanol on dopamine levels after chronic exposure: role of kappa opioid receptors. Karkhanis AN, Huggins KN, Rose JH, Jones SR.. Neuropharmacology. 2016;110(Pt A):190-197.
  9. Distinct effects of nalmefene on dopamine uptake rates and kappa opioid receptor activity in the nucleus accumbens following chronic intermittent ethanol exposure. Rose JH, Karkhanis AN, Steiniger-Brach B, Jones SR.. Int J Mol Sci. 2016;17(8):1216.
  10. Hyperactive KAPPA opioid receptors and increased presynaptic inhibitory regulation of dopamine after chronic alcohol exposure in mice and monkeys [abstract]. Siciliano CA, Rose JH, Fordahl SC, Karkhanis AN, Melchior JR, Jones SR.. Alcohol Clin Exp Res. 2016;40(Suppl 1):288A.