The Huang Lab at Case Western Reserve
University School of Medicine
Wolstein Research Building Room 6402
Alex Y. Huang
2103 Cornell Road,
Cleveland, Ohio 44106-7288 USA.
Tumor immunology, immunotherapy, immune cell migration in vivo, two-photon microscopy
- Dr. Huang received a B.S. in chemistry and an M.S. in biochemistry and molecular biology from the University of Chicago.
- He then entered the medical scientist training program at the Johns Hopkins University School of Medicine where he completed his Ph.D. thesis in the laboratory of Drew M. Pardoll, M.D., Ph.D.
- Dr. Huang’s Ph.D. thesis included studying the process of in vivo tumor-antigen cross-presentation by bone marrow derived professional antigen presenting cells and identified the dominant MHC class-I restricted tumor rejection antigen, AH-1, in a murine colon tumor model.
- After completing pediatric residency at Johns Hopkins Hospital, Dr. Huang entered the combined pediatric hematology/oncology clinical fellowship training program at Johns Hopkins Hospital and the National Cancer Institute.
- While a postdoctoral fellow in the laboratory of Dr. Ronald N. Germain in the Laboratory of Immunology at NIAID, Dr. Huang received the Cancer Research Institute Postdoctoral Fellowship Award and was among the first to develop the new technique of intravital 2-photon laser scanning microscopy in studying immune cell migration and interaction in secondary lymphoid organs and the gastrointestinal track in vivo.
- In 2006, Dr. Huang joined the Case Western Reserve University School of Medicine faculty as an Assistant Professor in the Division of Pediatric Hematology / Oncology at Rainbow Babies & Children’s Hospital - Rainbow / Ireland Cancer Center with a secondary faculty appointment in the Department of Pathology, Biomedical Engineering and General Medical Sciences, with membership in the Case Comprehensive Cancer Center.
- Currently, Dr. Huang is also the director of clinical fellowship program in Pediatric Hematology / Oncology, and the holder of the Theresia G. & Stuart F. Kline Family Foundation Chair in Pediatric Oncology since 2014.
- Dr. Huang was promoted to Associate Professor in 2012, tenured in 2014, and Professor in 2017.
- Currently, Dr. Huang is a member of the St. Baldrick's Foundation Scientific Advisory Board, Executive Scientific Committee of the Harrington's Discovery Institute, Leader of the Tumor Immunology & Immunotherapy interest group as well as co-leader of the Hematopoiesis & Immune Cell Biology Program at the Case Comprehensive Cancer Center.
- Dr. Huang’s laboratory research program is focused on adapting intravital 2-photon laser scanning microscopy to study various aspects of in vivo immunity and pathogenesis.
- These efforts include investigating the role of tumor microenvironment in immune cell recruitment and tolerance induction, interplay between chronic inflammatory conditions with carcinogenesis of the gastrointestinal track, regulation of T cell receptor activation by inflammatory chemokines, and mechanisms of pathogenic lymphocyte recruitment induction in animal models of multiple sclerosis.