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United States

Washington University,
School of Medicine,
St. Louis, MO

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Alaullah Sheikh

Address:

660 S Euclid,
Campus Box- 8051,
Infectious Diseases Division,
7th floor MPRB,
St. Louis, MO, 63110.

Research Interests:

Enteric pathogens, Bacterial pathogenesis, Pathogen-host interactions, Host responses, Vaccine

Biography:

Publications:

  1. Transcutaneous immunization with Clostridium difficile toxoid A induces systemic and mucosal immune responses and toxin A-neutralizing antibodies in mice.
  2. Enterotoxigenic Escherichia coli secretes a highly conserved mucin-degrading metalloprotease to effectively engage intestinal epithelial cells.
  3. Comparative proteomic analysis of the PhoP regulon in Salmonella enterica serovar Typhi versus Typhimurium.
  4. EatA, an immunogenic protective antigen of enterotoxigenic Escherichia coli, degrades intestinal mucin.
  5. Zinc influences innate immune responses in children with enterotoxigenic Escherichia coli-induced diarrhea.
  6. Natural selection in a bangladeshi population from the cholera-endemic ganges river delta.
  7. In vivo expression of Salmonella enterica serotype Typhi genes in the blood of patients with typhoid fever in Bangladesh.
  8. Characterization of anti-Salmonella enterica serotype Typhi antibody responses in bacteremic Bangladeshi patients by an immunoaffinity proteomics-based technology.
  9. Transcriptional modulation of enterotoxigenic Escherichia coli virulence genes in response to epithelial cell interactions.
  10. Memory T-cell responses to Vibrio cholerae O1 infection.
  11. Novel antigens for enterotoxigenic Escherichia coli vaccines.
  12. Salmonella enterica serovar Typhi-specific immunoglobulin A antibody responses in plasma and antibody in lymphocyte supernatant specimens in Bangladeshi patients with suspected typhoid fever.