Tuberculosis Drug Discovery

Tuberculosis (TB) is a major global health issue, causing over 1 million deaths each year. The discovery of new drugs to treat TB has become an urgent priority, as current treatments are inadequate and the emergence of drug-resistant strains of the bacterium poses a particular challenge. Drug discovery for TB is a highly complex and challenging process, with a variety of potential strategies being employed. These include screening of existing compounds, structure-based design approaches, novel chemical synthesis strategies, and natural product-based approaches. Each of these strategies has advantages and limitations, so combinations of approaches are often used to identify and optimize new drug candidates. Through these efforts, new compounds with potential for the treatment of TB have been discovered, providing hope for improved therapies in the future.