Prostacyclin

Prostacyclin is a powerful, short-acting vasodilator that plays a pivotal role in the maintenance of vascular homeostasis. It is a naturally occurring bioactive lipid that is produced mainly by the endothelial cells of blood vessels. Prostacyclin is known to have anti-inflammatory and anti-thrombotic activities, and it has been found to be involved in the regulation of vascular tone, cell proliferation and cell migration. It also influences microcirculatory perfusion and platelet aggregation, making it a vital pathway in preventing cardiovascular disease. Prostacyclin has many clinical applications, from treating pulmonary hypertension to prevention of restenosis after angioplasty. In addition, prostacyclin has been studied as a potential agent in treating diseases associated with abnormal blood vessel remodeling, such as rheumatoid arthritis.