Pathogenicity

Island Pathogenicity Islands (PIs) are pieces of DNA found in certain bacteria that are associated with virulence. They are believed to have arisen by horizontal gene transfer and are thought to contribute to a bacterial population’s ability to infect and cause disease in humans, animals and plants. PIs can contain genes for the production of toxins and other molecules that aid in the ability of a bacterial population to cause disease. As such, PIs can be used in a variety of ways, including the development of vaccines, diagnostics and treatments for bacterial infections. Ultimately, understanding PIs is vital for improving public health and halting the spread of disease.