Research Topic · Peer-Reviewed

Mouse Models

Mouse models are laboratory mice engineered or selected to reproduce features of human biology and disease, serving as essential tools for studying mechanisms of illness and testing potential therapies. Because mice share much of their genome and physiology with humans, can be genetically manipulated, and reproduce …

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 12× across the literature 🔖 ISSN 2997-1977

Overview

Mouse models are laboratory mice engineered or selected to reproduce features of human biology and disease, serving as essential tools for studying mechanisms of illness and testing potential therapies. Because mice share much of their genome and physiology with humans, can be genetically manipulated, and reproduce rapidly, they allow researchers to investigate gene function, disease progression, and treatment responses under controlled conditions that would be impossible in human subjects. Common approaches include transgenic mice that carry added genes, knockout mice in which specific genes are inactivated, and chemically or surgically induced models, each designed to capture particular aspects of a disease. Mouse models are used across virtually every area of biomedical research, including cancer, neurodegeneration, metabolism, immunology, and aging. Research relevant to this field includes work on tumor development in p53 knockout mice, which use a defined genetic deficiency to study cancer susceptibility, and studies of learning and memory in long-lived Ames dwarf mice as a model of longevity. By providing tractable systems in which to dissect the biology of disease, mouse models bridge basic discovery and clinical application. This page gathers peer-reviewed, open-access material relevant to the design and use of mouse models in the study of disease.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 12 articles above have been cited 12 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Nov 2026.

A sample of recent works citing this journal's research on Mouse Models, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Journal of Diseases (ISSN 2997-1977).

Journal editorial board
Charles Edward Rupprecht · United States Dr. Md. Rabiul Islam · Bangladesh Madalena Barroso · Germany

This page summarises published research for orientation; it is not medical or professional advice.