Sepsis is a life-threatening syndrome of organ dysfunction caused by a dysregulated host response to infection. Pathophysiologically it involves widespread inflammatory and immunosuppressive signaling, endothelial injury, microvascular dysfunction, and coagulopathy that can progress to septic shock, characterized by…
Sepsis is a life-threatening syndrome of organ dysfunction caused by a dysregulated host response to infection. Pathophysiologically it involves widespread inflammatory and immunosuppressive signaling, endothelial injury, microvascular dysfunction, and coagulopathy that can progress to septic shock, characterized by circulatory and metabolic derangement and persistent hypotension. Early recognition using clinical and laboratory criteria, prompt source control, timely antimicrobial therapy, hemodynamic resuscitation, and organ support are the cornerstones of management, while biomarkers and inflammatory cytokines aid risk stratification and monitoring. Research grouped under this topic reflects sepsis as a multisystem critical-care problem. Studies address rehabilitation of sepsis survivors in the intensive care unit, cardiac sequelae such as myocardial calcification after severe sepsis, and antimicrobial stewardship in neonatal units. Related work examines systemic inflammatory response syndrome and its cytokine profile in experimental models, lactic acidosis, acute respiratory distress and oxygenation assessment, coagulation abnormalities in severe illness, and biomarkers including natriuretic peptides and microRNAs used to predict morbidity and mortality. Severity scoring for infection-driven critical illness is also represented. This peer-reviewed literature supports clinicians and investigators working on early diagnosis, organ-support strategies, inflammation biology, and outcomes across the continuum of sepsis care.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 26 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Sepsis, linking to each citing work.