Electron Transfer Dissociation
Electron Transfer Dissociation (ETD) is a technique used in mass spectrometry to fragment monoanionic species. It is a mild fragmentation technique, producing low- and medium-energy c- and z-type product ions. This makes ETD particularly suitable for the analysis of delicate and large molecules, such as proteins and polymers. The fragmentation pattern obtained with ETD is often highly structurally informative, enabling an accurate identification of the peptide, protein or polymer being studied. Furthermore, since ETD involves fewer steps, it can be used to increase the speed and throughput of mass spectrometric measurements. As such, ETD is widely used in proteomics and polymer analysis studies.
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