Cross Linking Mass Spectrometry

Cross Linking Mass Spectrometry (CLMS) is an analytical technique that couples two different mass spectrometry (MS) techniques to provide a powerful tool for the analysis of complex protein structures. CLMS enables researchers to study interactions between proteins, peptides, and other biomolecules. It has a range of applications including drug discovery, enzyme construction and analysis, and investigating the structure and function of proteins. It is also used in studies of protein modifications, conformational changes of proteins, and protein-ligand binding. By providing information on the conformation and interactions of biomolecules, CLMS has become a powerful tool for understanding the mechanisms of disease and developing new therapeutic strategies.