Sepsis is a life-threatening syndrome of organ dysfunction caused by a dysregulated host response to infection. Rather than the infection itself, it is the body's exaggerated and damaging immune and inflammatory reaction, with widespread cytokine release, endothelial injury, coagulation disturbance, and impaired tis…
Sepsis is a life-threatening syndrome of organ dysfunction caused by a dysregulated host response to infection. Rather than the infection itself, it is the body's exaggerated and damaging immune and inflammatory reaction, with widespread cytokine release, endothelial injury, coagulation disturbance, and impaired tissue perfusion, that drives the harm. Progression to septic shock, marked by profound circulatory and metabolic derangement, carries high mortality and constitutes a medical emergency in which early recognition, source control, antimicrobial therapy, and hemodynamic support are decisive. Pathophysiology involves the systemic inflammatory response, lactic acidosis from tissue hypoxia, and downstream multi-organ failure, and outcomes depend on prompt risk stratification and management. Research in this area addresses rehabilitation of sepsis survivors in intensive care, cardiac sequelae such as rapid myocardial calcification after severe sepsis, restriction of antimicrobial use in neonatal units, experimental models of systemic inflammatory response syndrome, the diagnostic value of biomarkers and assessment scores for mortality risk, and the management of related critical illness including acute respiratory distress syndrome. The journal publishes peer-reviewed studies on the pathophysiology, diagnosis, biomarkers, management, and rehabilitation of sepsis and associated systemic inflammatory and critical-care conditions.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 15 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Sepsis, linking to each citing work.