Basal cells are the proliferative cells of the epidermal basal layer, the stratum basale, anchored to the basement membrane and responsible for continuously generating the keratinocytes that populate and renew the overlying epidermis. As the regenerative compartment of the skin, they sustain barrier integrity, repai…
Basal cells are the proliferative cells of the epidermal basal layer, the stratum basale, anchored to the basement membrane and responsible for continuously generating the keratinocytes that populate and renew the overlying epidermis. As the regenerative compartment of the skin, they sustain barrier integrity, repair wounds, and replace cells lost through normal turnover. Malignant transformation of basal keratinocytes gives rise to basal cell carcinoma, the most common human skin cancer, which is typically locally invasive and strongly associated with cumulative ultraviolet exposure, while dysregulated signaling in the basal compartment underlies other neoplastic and proliferative skin conditions. Study of basal cells intersects with keratinocyte biology, epidermal stem-cell dynamics, and the epithelial transformations that drive cutaneous tumors. Research relevant to this area examines treatment of basal cell carcinoma through fractionated laser microporation with topical imiquimod, the role of human papillomavirus in virus-induced carcinogenesis, transcription-factor and NF-κB signaling in keratinocytes, epithelial-mesenchymal transition and cancer stem-cell phenotypes at the dermo-epidermal junction, eccrine porocarcinoma, and the characterization of intraepithelial and benign lesions. The journal publishes peer-reviewed studies on basal and epidermal cell biology, keratinocyte renewal, and the pathology and treatment of basal cell carcinoma and related cutaneous neoplasms.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 25 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Basal Cells, linking to each citing work.