Research Topic · Peer-Reviewed

HIV/AIDS and Immune Activation

HIV/AIDS and immune activation describes the chronic, dysregulated stimulation of the immune system that accompanies human immunodeficiency virus infection and serves as a central driver of disease progression and non-AIDS comorbidity. HIV preferentially infects and depletes CD4-positive T lymphocytes while triggeri…

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 27× across the literature 🔖 ISSN 2324-7339 🗓 Reviewed June 2026

Overview

HIV/AIDS and immune activation describes the chronic, dysregulated stimulation of the immune system that accompanies human immunodeficiency virus infection and serves as a central driver of disease progression and non-AIDS comorbidity. HIV preferentially infects and depletes CD4-positive T lymphocytes while triggering persistent inflammation, microbial translocation, and innate and adaptive immune activation that continue even when viral replication is suppressed by antiretroviral therapy. Sustained activation contributes to immune exhaustion, accelerated immunosenescence, and end-organ injury, making it a key target for understanding why immune recovery is often incomplete. Investigative threads relevant to this area include the immunological and clinical effects of antiviral and phytochemical interventions on seropositive individuals, the cellular consequences of reverse transcriptase inhibitors, and the broader clinical profiles of HIV-infected patients in the antiretroviral era. Associations between HIV and malignancies such as conjunctival squamous cell carcinoma further illustrate how immune dysfunction shapes downstream pathology. Behavioral, adherence, and prevention research situates these biological processes within real-world care delivery across diverse populations. The peer-reviewed research collected here spans HIV immunology, antiretroviral therapy and its adverse effects, adjunctive interventions, and the clinical management of infection, reflecting the relevance of immune activation to the pathogenesis and treatment of HIV and AIDS.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

2014

Phytochemicals May Arrest HIV-1 Progression

Sharma B.Corresponding author
Department of Biochemistry, Faculty of Science,
Clinical Research In HIV AIDS And Prevention Cited by 5 doi:10.14302/issn.2324-7339.jcrhap-13-edt.1.3
2013

Pattern of Use of Highly Active Antiretroviral Therapy Regimens and Pattern of Occurrence of Adverse Drug Reactions in an Indian Human Immunodeficiency Virus Positive Patients

Rajesh RadhakrishnanCorresponding author
Radhakrishnan Rajesh M.Pharm, Asst Professor (Senior Grade), Department of Pharmacy Practice, Manipal College of pharmaceutical Sciences, Manipal University, Manipal- 576 104, Karnataka, India.
Clinical Research In HIV AIDS And Prevention Cited by 1 doi:10.14302/issn.2324-7339.jcrhap-12-174

How this research is being cited

The 12 articles above have been cited 27 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on HIV/AIDS and Immune Activation, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Clinical Research In HIV AIDS And Prevention (ISSN 2324-7339).

Journal editorial board
Manoj Sarma · United States Mohammed Merzah · Hungary Marta Talavera · Spain

This page summarises published research for orientation; it is not medical or professional advice.