Epidermal Growth Factor

Overview

Epidermal growth factor (EGF) is a 53-amino-acid polypeptide that binds the epidermal growth factor receptor (EGFR/ErbB1), a receptor tyrosine kinase whose activation triggers downstream RAS-MAPK and PI3K-AKT signaling to drive cell proliferation, survival, migration, and differentiation. The EGF/EGFR axis is central to epithelial tissue maintenance, wound healing, and angiogenesis, and its dysregulation contributes to oncogenesis, making EGFR a major target for tyrosine-kinase inhibitors and monoclonal antibodies in cancer therapy. Research associated with this topic reflects both the regenerative and oncological dimensions of growth-factor biology. Studies address wound healing and tissue repair, including the influence of acute versus chronic wound fluid in three-dimensional in-vitro models and amniotic membrane treatment of severe epidermal injury, alongside tissue-engineering approaches using stem cells. Oncology-focused work examines EGFR-directed therapeutics such as erlotinib and lapatinib, proteomic responses to targeted agents, biomarker discovery in carcinomas and sarcomas, and signaling pathways governing metastasis and epithelial-mesenchymal transition. Collectively, this peer-reviewed literature illustrates how EGF-related signaling informs regenerative medicine, molecular oncology, and the development and evaluation of receptor-targeted treatments across human and comparative models.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 12 articles above have been cited 47 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Nov 2026.

• Engineering a reproducible 3D wound model with defined macrophage polarization and partial-thickness mechanical injury
  2026 · Research Square
• BDDN: bayesian dynamic differential network analysis in cancer proteomics
  2026 · BMC Bioinformatics
• Engineering a 3D wounded skin equivalent to study early inflammatory and regenerative responses in vitro
  Rima Nuwayhid et al. · 2025 · Frontiers in Bioengineering and Biotechnology
• Engineering a 3D wounded skin equivalent to study early inflammatory and regenerative responses in vitro
  2025 · Frontiers in Bioengineering and Biotechnology
• Safety and Toxicity Evaluation of Stem Cell‐Based Vocal Fold Implant in Swine
  2025 · The Laryngoscope
• Biological properties and surgical applications of the human amniotic membrane
  J. R. Muñoz-Torres et al. · 2023 · Frontiers in Bioengineering and Biotechnology
• Characterization of Expression and Function of the Formins FHOD1, INF2, and DAAM1 in HER2-Positive Breast Cancer
  2023 · Journal of Breast Cancer
• Biological properties and surgical applications of the human amniotic membrane
  2023 · Frontiers in Bioengineering and Biotechnology

A sample of recent works citing this journal's research on Epidermal Growth Factor, linking to each citing work.

This page summarises published research for orientation; it is not medical or professional advice.

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