Chromosome Conformation Capture

Chromosome conformation capture (3C) is a powerful technique used to study the three-dimensional structure of chromosomes and measure their interactions in cells. It is an unprecedentedly accurate tool that can measure long-range interactions and identify regulatory elements in the genome. The technique has several applications, including mapping regulatory and structural elements, associating genes with active regulatory regions, and determining chromatin remodelling events. By providing insights into the epigenetic control of gene expression, 3C has enabled researchers to gain a better understanding of the biological mechanisms responsible for various diseases and has enabled the development of novel therapeutic strategies. The technique has also enabled the prediction of disease-associated gene-regulatory variants, making it an invaluable tool in the study of diseases.