Research Topic · Peer-Reviewed

Cervical Cancer Causes

Cervical cancer causes are the factors that initiate and promote malignant transformation of the cervical epithelium. The principal and necessary cause is persistent infection with high-risk human papillomavirus, a sexually transmitted DNA virus; types such as 16 and 18 are responsible for most cases. While most HPV…

Curated from this journal's research 📚 6 peer-reviewed articles cited Cited 1× across the literature 🔖 ISSN 2997-2108

Overview

Cervical cancer causes are the factors that initiate and promote malignant transformation of the cervical epithelium. The principal and necessary cause is persistent infection with high-risk human papillomavirus, a sexually transmitted DNA virus; types such as 16 and 18 are responsible for most cases. While most HPV infections clear spontaneously, persistence of a high-risk genotype drives carcinogenesis through expression of the viral oncoproteins E6 and E7, which inactivate the p53 and retinoblastoma tumor-suppressor pathways, deregulate the cell cycle, and impair apoptosis and genomic stability. These events promote stepwise progression from normal epithelium through cervical intraepithelial neoplasia to invasive carcinoma, with activation of downstream signaling pathways, including PI3K/AKT/mTOR, contributing to tumor development. Cofactors that increase the likelihood of persistence and progression include early or multiple sexual partners and other sexually transmitted infections, immunosuppression, tobacco use, long-term hormonal influences, high parity, and limited access to screening that would otherwise detect and treat precancerous lesions. Because the underlying cause is a vaccine-preventable infection, primary prevention through HPV vaccination and secondary prevention through HPV-based and cytologic screening are central to reducing incidence. Research examines the role of HPV in virus-induced carcinogenesis, the signaling alterations found in cervical tumors, and the behavioral and access-related cofactors that shape disease risk.

Research published in this journal

6 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 6 articles above have been cited 1 time in the scholarly literature. Citation data via OpenAlex and Crossref, updated Nov 2026.

A sample of recent works citing this journal's research on Cervical Cancer Causes, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Journal of Cervical Cancer (ISSN 2997-2108).

Journal editorial board
Hong Zhang · China Bharat Rekhi · India

This page summarises published research for orientation; it is not medical or professional advice.