Sickle Cell Disease
Sickle cell disease is a group of inherited red blood cell disorders caused by a change in the structure of the hemoglobin molecule. It is characterized by red blood cells that form an abnormal sickle shape, resulting in reduced oxygen-carrying capacity and a tendency to break apart easily. People with sickle cell disease have episodes of painful symptoms, including swelling in joints, abdominal pain and anemia, which can lead to severe organ damage. They are also at high risk for infection. Sickle cell disease is prevalent in people from African, Caribbean, Middle Eastern, and Mediterranean backgrounds, and it is the most common inherited blood disorder in the United States. Treatment of sickle cell disease usually involves medications to reduce pain and complications, blood transfusions to raise hemoglobin levels, and in some cases, a bone marrow or stem cell transplant. Early diagnosis and treatment of sickle cell disease can help reduce its impact and improve quality of life.
← Journal of Bone Marrow Biology