Research Topic · Peer-Reviewed

Neutrophils

Neutrophils are the most abundant circulating leukocytes in humans and the principal effector cells of the innate immune response to bacterial and fungal infection. Derived from myeloid progenitors in the bone marrow through granulopoiesis, they are released into the blood as terminally differentiated, short-lived p…

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 58× across the literature 🗓 Reviewed June 2026

Overview

Neutrophils are the most abundant circulating leukocytes in humans and the principal effector cells of the innate immune response to bacterial and fungal infection. Derived from myeloid progenitors in the bone marrow through granulopoiesis, they are released into the blood as terminally differentiated, short-lived phagocytes characterized by a multilobed nucleus and cytoplasmic granules containing antimicrobial enzymes such as myeloperoxidase and elastase. On recruitment to sites of inflammation by chemotactic gradients, neutrophils kill pathogens through phagocytosis, degranulation, generation of reactive oxygen species via the respiratory burst, and the extrusion of neutrophil extracellular traps. Their numbers and functional state are tightly regulated, and quantitative shifts inform clinical assessment: the neutrophil-to-lymphocyte ratio, for example, serves as an accessible marker of systemic inflammation and has been studied as a prognostic indicator in malignancy and other conditions. Disordered granulopoiesis, chemotherapy-induced myelosuppression, and dysregulated neutrophil activity contribute to immunodeficiency, tissue damage, and immunopathology in infectious and inflammatory disease. As a subject within bone marrow and hematological biology, the study of neutrophils spans their production, lifespan, antimicrobial mechanisms, regulation of oxidative responses, and value as diagnostic and prognostic biomarkers across a range of pathologies.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

2020

The Elliptical Aggregates – Idiopathic Granulomatous Mastitis

Bajaj AnubhaCorresponding author
MD. (Pathology) Panjab University, Department of Histopathology, A.B. Diagnostics, A-1, Ring Road, Rajouri Garden, New Delhi, 110027, India.
Exact topic International Journal of Infection Prevention Cited by 2 doi:10.14302/issn.2690-4837.ijip-19-3145
2017

Frailty and the Immune System

Wilson DaisyCorresponding author
Institute of Ageing and Inflammation, University of Birmingham, Edgbaston, Birmingham, UK, B15 2GW
Exact topic Aging Research And Healthcare Cited by 19 doi:10.14302/issn.2474-7785.jarh-17-1578

How this research is being cited

The 12 articles above have been cited 58 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Neutrophils, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Bone Marrow Biology.

Journal editorial board
Azad Saei · Sweden Shanmuganathan Chandrakasan · United States Sadanand Fulzele · United States

This page summarises published research for orientation; it is not medical or professional advice.