Adrenoleukodystrophy

Adrenoleukodystrophy (ALD) is an inherited disorder caused by a genetic mutation that affects the nervous system and adrenal glands. Symptoms usually appear in childhood and can include difficulty walking, poor balance, loss of intellectual and speech abilities, impaired vision and hearing, and seizures. In the severe form of the disease, the brain’s protective covering (myelin sheath) is destroyed. This can lead to severe mental and physical disability. Treatment options for ALD depend on the type and severity of the disorder, but can include enzyme replacement therapy, dietary changes, medications, and stem cell transplants. Early diagnosis and treatment can help improve outcomes and slow the progression of the disorder. ALD affects approximately 1 in 18,000 people worldwide and can have a significant impact on the affected individual and their family.