Research Topic · Peer-Reviewed

Diabetic Kidney Disease

Diabetic kidney disease, also called diabetic nephropathy, is a progressive complication of type 1 and type 2 diabetes in which chronic hyperglycemia damages the kidneys' filtering structures. It is among the most common microvascular complications of diabetes and a leading cause of chronic kidney disease and end-st…

Curated from this journal's research 📚 10 peer-reviewed articles cited Cited 165× across the literature 🔖 ISSN 2374-9431 🗓 Reviewed October 2026

Overview

Diabetic kidney disease, also called diabetic nephropathy, is a progressive complication of type 1 and type 2 diabetes in which chronic hyperglycemia damages the kidneys' filtering structures. It is among the most common microvascular complications of diabetes and a leading cause of chronic kidney disease and end-stage renal failure worldwide. The disease develops as sustained high blood glucose, often compounded by hypertension, injures the glomeruli, leading to thickening of the basement membrane, mesangial expansion, and increased permeability that allows protein, initially albumin, to leak into the urine. Clinically it is marked by albuminuria, declining glomerular filtration rate, and rising blood pressure, with oxidative stress and inflammatory mediators contributing to ongoing damage. Research in this area uses bioinformatic resources to identify genes, pathways, and biomarkers relevant to nephropathy, and investigates relationships between diabetes, metabolic markers, advanced oxidation products, and inflammation in patients, including those on dialysis. Management focuses on glycemic and blood-pressure control, reduction of proteinuria, and protection of remaining kidney function, while complementary and pharmacological agents are studied for renoprotective effects. Understanding diabetic kidney disease integrates metabolic, vascular, genetic, and inflammatory mechanisms to enable earlier detection and to slow progression toward kidney failure.

Research published in this journal

10 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 10 articles above have been cited 165 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Diabetic Kidney Disease, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Bioinformatics and Diabetes (ISSN 2374-9431).

Journal editorial board
Lijun Zhang · united states Chol Hee Jung · Australia Emile Chimusa · United Kingdom

This page summarises published research for orientation; it is not medical or professional advice.