Genetics of Parkinson?s Disease
Parkinson’s disease (PD) is a chronic and progressive neurodegenerative disorder causing motor and non-motor symptoms. Genetics play a key role in PD, as around 15-20% of all diagnoses are thought to have a hereditary component. Researchers have identified numerous genetic mutations associated with the development of PD, with the most common being a mutation in the LRRK2 gene. Other less common genetic mutations linked to PD include mutations in SNCA, PINK1 and PARK7. Knowing the genetic basis of PD allows scientists to develop better treatments and increase our understanding of the disease. It also helps in the identification of individuals at an increased risk of developing PD, which can help to improve early detection and management of the condition.
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