The authors have declared that no competing interests exist.
A functional state is a complex of properties of an organism that determines the level of its vital activity. The construction of human functional structures is based on the laws of nature. The golden proportion is a universal natural law and the highest manifestation of the structural and functional perfection of the organism, and has properties and principles: selfdevelopment, selforganization and selfregulation, balance and stability. It is found in the anatomical and physiological parameters of the human body, is a method for finding an extremum in solving problems of their optimization. Proceeding from the fact that the functional state of the cardiovascular system is an integral indicator of the general state of the body and its adaptation, as a process of searching for the optimal functional state, we studied this indicator in 43 young people. At the same time, it was found that the subjects under conditions of functional rest and in a satisfactory state of compensatoryadaptive capabilities, i.e. in prenosological conditions, their adaptive potential lies in the range of two values of the golden proportions (F = 1.618; F2 = 2.618). Thus, the golden proportions form the boundaries of the functional corridor, outside of which there is a change in the prenosological state of the body, namely, with an adaptive potential of less than 1.618, a physiological norm takes place, and with more than 2.618, premorbid states. In this regard, it is proposed a scale for assessing the functional state, as well as an index of the likelihood of developing a premorbid state in an individual's body, based on the principles and constants of the golden ratio. The discriminatory ability and sensitivity of the proposed scale to the functional states of the organism were assessed.
International standards for the provision of medical care provide for the implementation of preventive measures aimed at preventing the occurrence of diseases already at the stage of their initial manifestations. At the same time, the existing system of primary prevention is still devoid of the most important element  objectification of the assessment of the functional state of the body at the level of a premorbid state, when, as a result of the inconsistency of the body's capabilities, the prerequisites for the development of the pathological process arise. Such a gap in the system of primary prevention is intended to fill the methodology of prenosological diagnostics, according to which the development of clinical forms of diseases is preceded by quite definite disorders of the functional state (FS) of the body, in which the nonspecific component of the general adaptation syndrome manifests itself in the form of varying degrees of tension in the regulatory systems. FS is a systemic response of the body, ensuring its adequacy to the requirements of the activity. The assessment of the FS of a practically healthy person is an object of prenosological diagnostics, in which the main criterion of health is not the presence or absence of diseases, but the level of the organism's adaptive capabilities
Prenosological, characterized by the tension of regulation mechanisms
Premorbid, where is decrease in the adaptive capabilities of the body.
At the same time, under the influence of negative factors that go beyond the functional and adaptive capabilities of the body, the presence of qualitative transitions in the state of physiological functions is also a regularity. They cause a number of changes in functional systems, change the regulatory and adaptive status of the body, determining the state of human health. Thus, the transition to each new gradation of adaptation is accompanied by qualitatively new changes in the FS.
In general biological terms, health can be defined as a harmonious unity of all kinds of metabolic processes in the body and manifested in the optimal functioning of its organs and systems
Thus, the concepts of "functional state" and "regulatoryadaptive status of the organism" in modern physiology are considered as an integral part of individual health and as one of the important criteria of health.
Monitoring the health of healthy people, that is, prenosological control, is a practical step towards dynamically assessing the state of adaptation and regulatory systems, identifying the very initial manifestations of their overstrain and, through their prevention, ensuring the preservation of the health of healthy people.
Therefore, the development of a noninvasive express method, criteria and scales for assessing the prenosological level of individual health and, on their basis, the creation of technology for remote prenosological diagnostics and monitoring of the health of a healthy contingent of the population is an urgent task of preventive medicine.
With this, we have previously developed and proposed a number of noninvasive methods and technologies for prenosological assessment of the levels of individual health of healthy people
As a justification of this approach, we note that the level of formalization of knowledge in prenosological diagnostics is currently quite high, therefore it is possible to use rigorous mathematical procedures and statistical methods for recognizing states in it.
The level of formalization of knowledge in prenosological diagnostics is currentl y quite high, therefore it is possible to use strict mathematical procedures and statistical methods for recognizing states in it. However, the existing approaches to the synthesis of criteria and algorithms for prenosological diagnostics do not fully use the capabilities of modern methods of mathematical data analysis. When developing integral criteria for assessing FS (functional state), empirical approaches prevail, in which the criteria are built by arithmetic combinations of recorded indicators. Classes of states according to individual criteria are distinguished by an expert method, and there is still no unified methodology and criteria for a reliable assessment of the levels of functioning of the human body
Thus, the golden proportions of physiological indicators act as markers of transient states. The revealed phenomenon of golden proportions represents a new direction in assessing the adaptive capabilities of the human body. In the light of the above, it can be argued that the problem of reliably determining a specific place of the functional state of a certain person in the space between norm and pathology, i.e. establishing the belonging of a given person to a certain class of functional states is an urgent task of prenosological diagnostics.
When solving this problem, it becomes necessary to use a special scale, which is the most important tool for processing and fixing information about the object under study and designed to ensure its optimal processing. Thus, the main purpose of the scaling procedure is the ability to assess the processes under study. The above facts and provisions made it possible to formulate the following objectives of our research:
Development, based on the principles and constants of the golden ratio, scales and criteria for assessing functional states and verification of prenosological levels of the body's health; Based on the survey data of the most informative, morphofunctional indicators of a practically healthy contingent of young people, to assess the possibilities of the proposed criteria and scale;  To develop methods and criteria for assessing the index of functional stability of the organism and the likelihood of its qualitative change. For practical health care, prenosological diagnostics, in accordance with the proposed scale, allowing an early assessment of the level of health and risk factors, opens the way to increasing the effectiveness of healthimproving measures and significantly complements the preventive principle in medicine.
Subject of research: In accordance with the goals, the subject of our research was the levels of the organism's adaptive potential as markers for assessing its functional state, as well as scales and criteria for their verification and interpretation.
In this work, we used statistical methods for quantitative and verbal assessment of examination results and methods for constructing medical rating scales.
As the most informative markers of the functional state of the organism, were used their adaptive potential, levels of somatic health and energy potential.
Among the entire spectrum of methods for analyzing the adaptive potential of a person, based on the assessment of various parameters of vital activity, the most informative are those that characterize the activity of the cardiovascular system (CVS)  the main indicator of all events occurring in the body. The formation of other systems largely depends on the state of this system, since, by participating in metabolic processes, the circulatory system determines the further viability of the entire organism as a whole.
In addition, this system plays a leading role in providing adaptation processes. We calculated AP, in arbitrary units  points, according to the formula of R. Baevsky
AP= 0,011 PR+0,014 SBP+0,008 DBP+0,014 A+0,009 BW0,009 H0,27.
To assess the level of physical health, we used the express method of G LApanasenko
Then is performed a functional test (Martinet's test). The recovery time of the heart rate is taken into account within 3 minutes.
Based on the obtained data, the following indices are calculated:
1. Mass index: Body weight, kg / (Height, m2), in kg / m2
2. Life index: VC, ml / (body weight, kg), ml / kg
3. Strength index: Hand strength, kg / Body weight, kg, in%
4. Robinson's index: (HRreste , beats / min) * (АДsystol) / 100, in conventional units.
5.Functional test (Martinet test)
The results obtained for all of the above indicators are evaluated in points. Summing up the scores for all five indicators and comparing them with the scale proposed by the author, the individual level of physical health of the subject was determined (low, below average, average, above average, high).
The quantitative assessment of the body's energy potential was determined by the Robinson index (RI). Note that this indicator characterizes the level of metabolic and energy processes occurring in the body and the systolic work of the heart, and together with the adaptive potential is the most sensitive marker of the state of the CVS and the adaptive mechanisms of the human body. At the same time, the assessment of RI, according to the criteria proposed by the authors  excellent indicates a high; good  about the normal functional reserve of the CVS; a, average  insufficient, bad and very bad  different levels of dysregulation of the CVS. According to the methods described above, 43 (24 girls and 19 boys) practically healthy students of youth aged 1725 were examined. During the work we used the methods of mathematical statistics and verbal marking of results of investigations and methods of creating medical marking scales.
When developing methods for quantitative assessment of the level of health, the correct assessment of the functional states of the body and systems that ensure the vital activity of the body as a whole is an important task. Since medicine deals with physiological processes, it operates, as necessary, with different numerical indicators, and connections between different characteristics. Currently, in medicine, many scales and criteria for assessments and classifications are used, for various conditions
Note that measurement in its broadest sense can be defined as assigning numbers to objects or events according to some rules. These rules should establish a correspondence between the properties of the objects in question and the numbers. In the theory of measurements, it is customary to distinguish four main types of scales: names, order, interval and relations. In this case, measurements carried out using the first two scales are considered qualitative and nonparametric criteria are used for their processing, and measurements made on the last two scales are quantitative in this case, parametric criteria are applied. In each scale, the properties of numbers assigned to objects or phenomena are strictly defined. In this regard, we have chosen the interval scale as a model of the scale for assessing FS.
In mathematical statistics, interval estimation is the result of using a sample to calculate the interval of possible values of an unknown parameter, the estimate of which must be constructed. An interval scale is a scale that classifies according to the principle "more by a certain number of units  less by a certain number of units." The use of an interval scale is also possible in the case when, using a certain criterion (measurement standard), it is possible to determine the magnitude of the difference in features not only by the type of more or less, but also by how many units one object or phenomenon differs from another. A unit of measurement is set for this measurement. The scale of intervals is a fully ordered series with calibrated intervals between ranks, with the counting starting from an arbitrary value from the chosen value (there is no absolute zero). As a result, a conclusion on the state of health is formed.
Below is one of the options for the scale, such a simplified interpretation of prenosological diagnoses.






High level of health; 

Optimum level of health; 

Deviations that can be easily corrected; 

Complete recovery of health is possible; 

Condition of diseases that are still compensated due to high voltage regulation systems 

The probable presence of pathology 
As you can see, medical rating and prognostic scales have their own characteristics, principles and approaches to construction. From the existing scales of functional states, we have adopted an interval scale and built its following model, which follows from modern concepts and corresponds to the views of Avicenna:
Intervals of functional state  1  2  3  4  5  6 
ModernOption 
Physiologicalnorm  Physiologicaloptimum  1prenosology Conditionstress  2prenosology ConditionOvervoltage  Premorbidfortunes  Pathology 
Avicenna's version 
body is healthy to the limit  body is healthy, but not to the limit  the body is not healthy, but not sick  body easily accepting health  the body is sick but not to the limit  the body is sick to the limit 
Thus, the scale we recommend has 6 physiological states  “corridors” and 5 possible qualitative transitions.
The next task is to determine the indicators characterizing these intervals, i.e. translate this verbal scale into a numerical one. It should be taken into account that the construction of a scale for assessing the functional state should be based on indicators acting on the principle of optimization and harmonization of the state of the body. Therefore, as an indicator of the scale of verification of the functional state of the organism, we have chosen the adaptive potential of its cardiovascular system that meets these requirements.
Since the functional state of the organism is subject to the hierarchical principle, i.e. Since a qualitative transition from one state to another is continuous, the upper boundary of each interval of the corridor is simultaneously the lower boundary of the next. Therefore, the scale proposed by us, with 6 intervals of states, is characterized by 12 boundaries, of which 5 are combined values. In accordance with the objectives of the study and taking into account the conclusions of
F^{0}, F^{1}, F^{2}, F^{3}, F^{4}, F^{5} (1)
F^{2}/2 , F^{3}/2, F^{4}/2 , F^{5}/2 (2)
Taking into account the above principles of constructing the proposed scale, from the numbers of series (1) and (2), we have compiled the following boundaries of the projected 6 intervals of functional states:
(F^{0 }÷ F^{2}/2); (F^{2}/2 ÷ F^{1}); (F
Taking into account the values of the constant of the golden ratio F = 1.6180033, the following numerical indicators An of the boundaries of 6 intervals of the scale are established:
А_{1} А_{2 } (1÷1,309);
А_{2} А_{3}  (1,309÷1,618);
А_{3} А_{4}  (1,618÷2,118);
А_{4} А_{5}  (2,118÷2,618);
А_{5} А_{6 } (2,618÷3,427);
А_{6 }А_{7}  (3,427÷4,236)
Thus, the scale we propose has the following criteria for the indicators of assessing states (
Thus, the developed scale and its criteria, and algorithms for assessing the indicators of the adaptive potential of the CVS, allow us to classify practically healthy individuals, according to the levels of the functional state. Its sufficient sensitivity and discriminatory properties are confirmed by the presence of a correlation between the scaling results and the indicators of those examined by the level of health and functional reserve of CVS.
The proposed scale, its criteria and methods of analysis, also make it possible to assess the levels of FS stability, within certain functional intervals and the likelihood of their qualitative changes in the direction of deterioration. As a result, it becomes possible to quantitatively assess functional states, their reserves and predict the occurrence of premorbid conditions, that is, to carry out prenosological monitoring of the health of healthy people and to determine the contingent of persons at risk of deteriorating health.