Oxidative stress diseases are conditions in which a sustained imbalance between the generation of reactive oxygen and nitrogen species and the capacity of antioxidant defenses contributes to tissue injury and disease progression. Excess reactive species, produced largely by mitochondrial respiration, NADPH oxidases,…
Oxidative stress diseases are conditions in which a sustained imbalance between the generation of reactive oxygen and nitrogen species and the capacity of antioxidant defenses contributes to tissue injury and disease progression. Excess reactive species, produced largely by mitochondrial respiration, NADPH oxidases, and inflammatory cells, damage lipids through peroxidation, oxidize proteins and nucleic acids, and perturb redox-sensitive signaling, processes implicated in cardiovascular disease, metabolic syndrome, hepatic injury, neurodegeneration, diabetic complications, and aging. Endogenous defenses, including superoxide dismutase, catalase, glutathione peroxidase, and small-molecule antioxidants, normally constrain this damage, and disease arises when production overwhelms or defenses are depleted. A central research aim is to determine whether augmenting antioxidant capacity, dietary or pharmacological, mitigates oxidative injury in defined disease models. The subject matter examined in this area includes antioxidant and hepatoprotective effects in models of induced oxidative stress, cardiovascular disorders provoked by L-NAME and high-fat diet, oxidative injury from hydrogen peroxide in cultured cells, advanced glycation and methylglyoxal-driven radical generation, testicular oxidative stress, and phytochemical protection in retinal and metabolic disease. The journal publishes peer-reviewed research on the mechanisms of oxidative-stress-related disease and antioxidant intervention.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 78 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Oxidative Stress Diseases, linking to each citing work.