Senile Plaques

Senile plaques are deposits of protein fragments and a sugar molecule that accumulate in the brains of people with Alzheimer's disease. They are composed of primarily amyloid beta (A?) peptide, a protein fragment that is formed by the breakdown of larger proteins, called APP, in the brain. Senile plaques form in the spaces between neurons and can interfere with the normal functioning of the brain. They are a hallmark of Alzheimer's and are thought to be the cause of the cognitive decline observed in those with the disease. Senile plaques have been studied extensively and are the focus of research into prevention and treatments for Alzheimer's. Other diseases, such as cerebral amyloid angiopathy, can also cause the formation of senile plaques.