Overview
Cellular senescence refers to the process in which cells stop dividing and undergo a state of growth arrest, which is a normal part of the aging process. Senescent cells are marked by decreased activity and altered cellular functions, which can contribute to the development of age-related diseases such as cancer, diabetes, and arthritis. Research on cellular senescence has revealed a potential for improving the quality of life in older adults by identifying and targeting specific cells that contribute to age-related health issues. The concept of targeting senescent cells in aged individuals is known as senotherapy. Senolytics are drugs developed to selectively eliminate senescent cells, while leaving healthy cells intact. The ability to specifically target harmful senescent cells with senolytics has shown promise in extending overall lifespan as well as reducing age-related diseases. Healthcare research has important implications for the development of senotherapy in the prevention and treatment of major age-related diseases. By focusing on cellular senescence, healthcare researchers have the potential to not only improve healthspan, but also lifespan, in older individuals. As the aging population increases globally, it is essential to maintain healthy aging and address the related healthcare challenges. Research focused on cellular senescence provides a promising avenue for innovative therapies that could improve the quality of life for aging populations.