Leukocyte Adhesion

Deficiency (LAD) Leukocyte Adhesion Deficiency (LAD) is a rare disease that is caused by genetic defects in the body’s ability to make adhesion molecules, which are needed for white blood cells (leukocytes) to move around the body and fight infections. People with LAD have an increased susceptibility to bacterial infections, which can become life-threatening if not treated quickly. In addition, many of these infections are caused by very virulent bacteria, including Staphylococcus aureus and Mycobacterium avium, which are difficult to treat. Treatment for LAD is focused on managing the infection and preventing it from occurring. This can include antibiotics, supportive care, bone marrow transplantation and gene therapy. With early diagnosis and prompt treatment, people with LAD can lead normal and healthy lives.