Research Topic · Peer-Reviewed

Chronic Myelogenous Leukemia (CML)

Chronic myelogenous leukemia (CML), also called chronic myeloid leukemia, is a cancer of the blood-forming cells of the bone marrow in which the body produces an excess of abnormal white blood cells. It is driven by a characteristic genetic abnormality, the Philadelphia chromosome, formed by a translocation between …

Curated from this journal's research 📚 2 peer-reviewed articles cited Cited 14× across the literature 🗓 Reviewed June 2026

Overview

Chronic myelogenous leukemia (CML), also called chronic myeloid leukemia, is a cancer of the blood-forming cells of the bone marrow in which the body produces an excess of abnormal white blood cells. It is driven by a characteristic genetic abnormality, the Philadelphia chromosome, formed by a translocation between chromosomes 9 and 22 that creates the BCR-ABL fusion gene and an overactive tyrosine kinase that pushes uncontrolled white-cell proliferation. CML most often affects older adults and may at first cause few symptoms, with fatigue, easy bruising, frequent infections, anemia, and an enlarged spleen developing as the disease progresses through its chronic, accelerated, and blast phases. The advent of tyrosine kinase inhibitors targeting BCR-ABL transformed CML from a frequently fatal disease into one that is, for many patients, manageable over the long term, making sustained medication adherence an important determinant of outcomes. Advances in Leukemia publishes peer-reviewed research relevant to leukemia biology and care, including a qualitative study of drivers and barriers to medication adherence in patients with chronic myeloid leukaemia. This page gathers open-access research relevant to the genetics, diagnosis, treatment, and management of chronic myelogenous leukemia.

Research published in this journal

2 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 2 articles above have been cited 14 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Chronic Myelogenous Leukemia (CML), linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Advances in Leukemia.

Journal editorial board
Hang Su · United States Ewelina Grywalska · Poland Antonio Ruggiero · Italy

This page summarises published research for orientation; it is not medical or professional advice.