Systemic lupus erythematosus (SLE) is a chronic autoimmune disease in which the immune system loses tolerance to the body's own tissues and produces autoantibodies that cause inflammation and damage across multiple organ systems. Commonly affected sites include the skin, joints, kidneys, blood, heart, lungs, and ner…
Systemic lupus erythematosus (SLE) is a chronic autoimmune disease in which the immune system loses tolerance to the body's own tissues and produces autoantibodies that cause inflammation and damage across multiple organ systems. Commonly affected sites include the skin, joints, kidneys, blood, heart, lungs, and nervous system, and the disease characteristically follows a relapsing-remitting course with periods of flare and remission. Clinical features vary widely and may include joint pain and swelling, a photosensitive facial rash, fatigue, fever, kidney involvement, and hematological abnormalities, reflecting the systemic and heterogeneous nature of the condition. SLE predominantly affects women, particularly during reproductive years, and its management centers on suppressing immune-mediated inflammation while minimizing organ damage and treatment side effects. Within rheumatology, SLE is a prototypical systemic autoimmune disorder, studied alongside other immune-mediated conditions of the joints and connective tissues, including the inflammatory arthritides encountered in pediatric and adult rheumatology practice. This page reflects the scope of advanced rheumatology science in examining autoimmune and inflammatory disease, and gathers peer-reviewed, open-access material relevant to the immunology, clinical features, and management of systemic lupus erythematosus.
2 peer-reviewed articles, ranked by relevance. Each links to its DOI.