Norepinephrine Transporter Polymorphisms

Norepinephrine Transporter (NET) Polymorphisms are genetic variants which affect the structure of the NET protein. This protein is responsible for the uptake and clearance of the neurotransmitter norepinephrine which is involved in a variety of functions, including alertness and arousal, inhibition of inflammation, and regulation of blood pressure. Therefore, NET polymorphisms are of great significance in understanding and treating various physiological disorders, such as anxiety and depression, cardiovascular diseases, neurological and autoimmune diseases. Furthermore, NET polymorphisms can also be used as a tool to predict the effectiveness and response of pharmacological treatments targeting NET.