Surgical Managment Of Intracranial Invasive Aspergillosis In Immunocompetent Patients : Results From 3 Case Reports

Cerebral aspergillosis is a severe disease most commonly suspected in immunodeficient patients. The objective of this study is to determine the role of surgery in management of intracranial aspergillosis. We report three cases of immunocompetent patients presenting: posteriror fossa aspergillosis, sphenoidal extended to sellar region aspergillosis and post operative aspergillosis without extracerebral involvement. Microbiology and histological examination were carried out to provide the diagnosis. The patients underwent surgical procedure associated with medical treatment or not. In one case, surgical treatment was efficient. The outcome was good in two cases. Conclusion: Rapid diagnosis of invasive aspergillosis applying radiological and surgical procedures and immediate ignition of antifungal can be life saving. DOI : 10.14302/issn.2470-5020.jnrt-16-1288 Corresponding Author : K QUENUM, Service de Neurochirurgie, hôpital des spécialitésRabat, Maroc.


Discussion
Cerebral aspergillosis is one of the common sites secondary to invasive aspergillosis from hematogenous dissemination (1,8) or contignous spread aspergillus from paranasal sinuses (2,3).Pulmonary involvement is rarely seen in immunocompetent patient unlike the immunosuppressed.The quest for blood supply especially the thalamic perforators explains its localizations around the substancia nigra.Posterior fossa lesions without other sites are rare, like in our case 1.
The clinical presentation is that of a posterior fossa space occupying lesions.Supra tentorial lesions are pleomorphic.They may present with functionnal neurological syndrome or raised intracranial pressure with sepsis syndrome.Risks factors for cerebral aspergillosis in an immunocompetents patients described in literature include old age, diabetes, alcoholism, illicit drug abuse and brain surgery like case 3 (6,9).Our patient case 1, presented with undiagnosed diabetes which was confirmed on admission.Brain CT scan with contrast may not suggest the diagnosis because the lesions are not located in the substancia nigra (6).Only MRI with spectroscopy could suggest an infectious process rather than tumour.This indicated stereotatic biopsy in our patient as a first step followed by bacteriological and histological examinations of the specimen which confirmed the diagnosis.Amphotéricin B is the reference drug in our department for its efficacy, In the literature, surgery was indicated in compressive (symptomatic) lesions or for diagnostic biopsy (3,5,8).
The treatment of choice for sino-orbital aspergillosis or sphenoidal is surgical excision of the aspergilloma, granulation tissue of the involved sinus for ventilation and drainage, as early as possible (1,5,7,8).
Furthermore, there was shown a beneficial effect of presurgical treatment with antifungal therapy (9,10).In patients for whom total removal cannot be achieved, intensive therapy with antifungal agents must be started immediately.But for the case 1, pre operative medical treatment was not satisfactory.
For the patient 3, it should be noted that all bacteriological samples performed in the theatre especially to identify nosocomial risks are unsuccessful.

Introduction 1 A
Cerebral aspergillosis is severe parasitic disease which is rare in immunocompetent individual.The invasive form with multiple visual involvements is usually seen with immunosuppression.New therapeutic agents such as voriconazole and capsofungine which are more save and efficacious have changed the outcome of this fatale cerebral infection.Case 47 year old patient with no previous medical history presented with features of raised intracranial pressure, statokinetic cerebellar syndrome as well as left sided hemiparesis.The diagnosis of posterior fossa space occupying lesion was made.Neuroradiologic investigations demonstrated posterior fossa lesions.Magnetic resonance imaging and spectroscopy were in favor of a multiple infective process (figure 1).Stereotatic biopsy was carried out on the patient and parasitological and histological examinations of the specimen concluded to a filamentous fungal infection of Aspergillus type.Culture and staining techniques categorized the specie as Aspergillus fumigatus (fig 2).Patient was placed on intra veinous amphotéricin B but this was complicated with acute active hydrocephalus warranting external ventricular drainage (fig3).Subsequently, he developped staphylococcal meningitis as day 8 post op, treated with intra veinous vancomycin.Patient developed renal insufficiency and hyperosmolar non ketotic coma for an unknown diabetis for which amphotéricine B therapy was stopped.His neurological status deteriorated with a Glasgow coma scale (GCS)7/15.Posterior fossa surgery was performed with excision of the fungal abscess (fig 4) and Voriconazol was instituded post operatively for fungal therapy with improvement of the neurological status to GCS 13/15.But the patient succumbed to acute cardiac failure.

Figure 2 :
Figure 2: ( A) filamentous fungal infection of Aspergillus type.Culture and staining techniques categorized the specie as Aspergillus fumigatus (B)

Figure 3 2 A
Figure 3: cerebral CT scan with axial view showing acute hydrocephalus (A) and control after external ventricular drainage (B)

Figure 4 :
Figure 4: cerebral CT scan pre operative (A) and post operative (B) after posterior fossa surgery with total removal or abscesses

Figure 5 :Figure 6 : 3 A
Figure 5: CT scan showing a hypodense mass enlarging the sphenoid sinus and sellar region with calcification like images and bone erosion of the sellar floor

Figure 7 :
Figure 7: (A) pre operative MRI, axial T1 weighted with enhancement of sphenoid wing meningioma.(B) : Ct scan showing an brain abscess in post op area; (C): CT scan after remoral sugery and 2 months medical treatment.
Cerebral aspergillosis is a serious disease; the diagnosis of which should be suspected in case of immunosuppression with search for primary focus in the lungs or paranasal sinuses.Therapy with antifungal agents still remain delicate.Surgical removal of sphenoid sinus aspergillosis cases proved to be efficient.Other sites infections must be completed by antifungal treatment (4).